Dr. Gyeong-Hun Baeg

Department of Anatomy, YLL School of Medicine

National University of Singapore, Singapore

Assistant Professor

Email: antbgh@nus.edu.sg

Qualifications

1999  Ph.D., in Biomedical Science (Physiology), Osaka University School of Medicine, Japan

1993  M.Sc., in Biology, Hokkaido University, Japan

Publications (selected)

1. KimB.-H.,KimM,, YinC.H., Jee J.-G., Sandoval C., LeeH.,BachE.A., Hahm D.-H.andBaegG.-H.(2011).Inhibition of JAK3 activity alleviates inflammation in monoarthritic rats.British Journal of Pharmacology164:106-118.
2. Kim B.-K., Jee J.-G., Yin C.H., Sandoval C., Jayabose S., Kitamura D., Bach E.A. andBaeg G.-H.(2010). NSC114792, a novel small molecule identified through structure-based computationaldatabase screening, selectively inhibits JAK3.Molecular Cancer9:36.
3. Kim B.-H., Oh S.R., Yin C.H., Lee S., Kim E.A., Kim M.S., Sandoval C., Jayabose S., Bach E.A., Lee H.K. andBaeg G.-H.*(2010).MS-1020 is a novel small molecule that selectively inhibits JAK3activity.British Journal of Haematology148:132-43.
4. Kim B.K., Yin, C.H., GuoQ., BachE.A., LeeH., SandovalC., JayaboseS., Hall D. andBaeg G.-H.(2008).A small molecule compound identified through a cell-based screeninginhibits JAK/STAT pathway signaling in human cancer cells.Molecular Cancer Therapeutics7:2672-80.
5. Bach A., Ekas L.A., Ayala A., Perrimon N.andBaeg G.-H.(2007).GFP reporters detect the activation of the Drosophila JAK/STAT pathwayin vivo.Gene Expression Pattern7; 323-331.
6. Ayala-Camargo A., Ekas L.A., Flaherty M.S.,Baeg G.-H.and Bach EA. (2007). The JAK/STAT regulates proximo-distal patterning inDrosophila.Developmental Dynamics236; 2721-2730.
7. Ekas A. L.,Baeg G.-H., et al. (2006). JAK/STAT signaling Promotes regional specification by negatively regulating winglessexpression inDrosophila.Development133; 4721-4729.
8. Baeg G.-H.,Zhou R. and Perrimon N. (2005). Identification of novel JAK/STAT signaling components by a cell-based genome-wide RNAi screen inDrosophila.Genes & Development19; 1860-1870.
9. Baeg G.-H., Selva E. M.,Goodman R. M., Dasgupta R.and Perrimon N. (2004). The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycans receptors.Developmental Biology276; 89-100.(Cover Article).
10. Liu C., Li Y., Semenov M., Han C.,Baeg G.-H., et al. (2002). Control ofb-Catenin Phosphorylation Degradation by a Dual-Kinase Mechanism.Cell108; 1-20.
11. Selva E., Hong K.,Baeg G.-H., et al. (2001). Dual role of the fringe connection gene in both heparan sulfate and fringe-dependent signaling events.Nature Cell Biol.3(9); 809-815.
12. Baeg G.-H., Lin X., Khare N., Baumgartner S. and Perrimon N. (2001). Heparan sulfate proteoglycans are critical for the organization of the extracellular distribution of Wingless.Development128; 87-94.
13. Baeg G.-H.and Perrimon N. (2000). Functional binding of secreted molecules to heparan sulfate proteoglycans inDrosophila.Curr. Opin. Cell Biol.12; 575-580.
14. Matsumine A., Ogai T., Senda N., Okumura K., Satoh T.,Baeg G.-H., Kawahara T., Kobayashi S., Okada M., Toyoshima K. and Akiyama T. (1996). Binding of APC to the human homolog of theDrosophilaDisc Large Tumor Suppressor Protein.Science272; 1020-1023.
15. Baeg G.-H., Matsumine A., Kuroda T., Bhattacharjee R. N., Miyashiro I., Toyoshima K. and Akiyama T. (1995). The tumor suppressor gene product APC blocks cell cycle progression from G0/G1 to S phase.EMBOJ. 14; 5618-5625.

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