Dr. Xinbo Li

Casey Eye Institute

Oregon Health and Science University, USA

Email: xinboli@hotmail.com

Qualifications

1995-1998 Ph.D., Shanghai Medical University, Shanghai, China

1992-1995 M.Sc., Shanghai Medical University, Shanghai, China

Publications (Selected)

1. Lynn BD, Li XB, and Nagy JI (2012). Under construction: building the macromolecular superstructure and signaling components of an electrical synapse. Journal of Membrane Biology. 245: 303-317. The first two authors contributed equally to this work.

2. Li XB, Lynn BD and Nagy JI. (2012) The effector and scaffolding proteins AF6 and MUPP1 interact with connexin36 and localize at gap junctions that form electrical synapses in rodent brain. Eur J Neurosci., 35:166-181.

3. Li, XB, Lu, S. and Nagy J.I. (2009) Direct binding of the first PDZ domain of ZO-2 and ZO-3 with the C-terminus of Connexin36. Neurochemistry International. 54:393-402.

4. Li, XB , Penes, M., Odermatt, B., Willecke, K., and Nagy, J.I. (2008) Ablation of Cx47 in transgenic mice leads to the loss of MUPP1, ZONAB and multiple connexins at astrocyte-oligodendrocyte gap junctions. Eur J Neurosci., 28:1503-1517.

5. Li, XB, Kamasawa N, Ciolofan, C., Olson, C., Lu, S., Davidson GV, Yasumura T, Shigemoto R., Rash, J.E., and Nagy, J.I. (2008) Connexin45-containing neuronal gap junctions in rodent retina also contain connexin36 in both apposed hemiplaques, forming bi-homotypic gap junctions, with scaffolding contributed by zonula occludens-1. Journal of Neuroscience. 28:9769-9789. L.X and K.N. contributed equally as first coauthors.

6. Flores CE, Li XB, Bennett MV, Nagy JI and Pereda AE. (2008) Interaction between connexin35 and zonula occludens 1 and its potential role in the regulation of electrical synapses. Proceedings of the National Academy of Sciences of the United States of America, 105(34):12545-12550.

7. Chen, V.C.*, Li, XB*, Perreault, H. and Nagy, J.I. (2006) Interaction of zonula occludens-1 (ZO-1) with alpha-actinin-4: application of functional proteomics for identification of PDZ domain-associated proteins. J Proteome Res. 5(9):2123-2134. *C.V. and L.X contributed equally as first coauthors.

8. Ciolofan C*, Li XB*, Olson C, Kamasawa N, Gebhardt BR, Yasumura, Morita m, Rash JE and Nagy JI. (2006) Association of connexin36 and zonula occludens-1 with zonula occludens-2 and the transcription factor zonula occludens-1-associated nucleic acid-binding protein at neuronal gap junctions in rodent retina. Neuroscience. 140(2):433-451. *C. C and L. X Contributed equally as first authors to this work.

9. Penes, M.C.*, Li, XB*, Nagy, J.I. (2005) Expression of Zonula Occludens-1 (ZO-1) and the transcription factor ZO-1-associated nucleic acid-binding protein (ZONAB)-MsY3 in glial cells and colocalization at oligodendrocyte and astrocyte gap junctions in mouse brain. Eur. J Neurosci. 22:404-418. *P.M. and L.X contributed equally to this work.

10. Li, XB, Olson, C., Lu, Shijun, Nagy, J.I. (2004) Association of connexin36 with zonula occludens-1 in HeLa cells, betaTC-3 cells, pancreas, and adrenal gland. Histochem. Cell Biol. 22:485-498.

11. Li, XB, Ionescu, A.V., Lynn, B.D., Lu, S., Kamasawa, N., Morita, M., Davidson, K.G., Yasumura, T., Rash, J.E., Nagy, J.I. (2004) Connexin47, connexin29 and connexin32 co-expression in oligodendrocytes and Cx47 association with zonula occludens-1 (ZO-1) in mouse brain. Neuroscience. 126:611-630.

12. Rash JE, Pereda A, Kamasawa N, Furman CS, Yasumura T, Davidson KG, Dudek FE, Olson C, Li XB, Nagy JI. (2004) High-resolution proteomic mapping in the vertebrate central nervous system: close proximity of connexin35 to NMDA glutamate receptor clusters and co-localization of connexin36 with immunoreactivity for zonula occludens protein-1 (ZO-1). J. Neurocytol. 33:131-151.

14. Li XB, Olson C, Lu S, Kamasawa N, Yasumura T, Rash JE, Nagy JI. (2004) Neuronal connexin36 association with zonula occludens-1 protein (ZO-1) in mouse brain and interaction with the first PDZ domain of ZO-1. Eur. J Neurosci. 19:2132-2146.

15. Li XB, Lynn BD, Olson C, Meier C, Davidson KG, Yasumura T, Rash JE, Nagy JI. (2002) Connexin29 expression, immunocytochemistry and freeze-fracture replica immunogold labelling (FRIL) in sciatic nerve. Eur. J Neurosci. 16:795-806.

16. Nagy JI, Li XB, Rempel J, Stelmack G, Patel D, Staines WA, Yasumura T, Rash JE. (2001) Connexin26 in adult rodent central nervous system: demonstration at astrocytic gap junctions and colocalization with connexin30 and connexin43. J Comp. Neurol. 441:301-323.

17. Lynn. B.D., Li, XB, Cattini, P.A., Turley, E.A., Nagy JI. (2001) Identification of sequence, protein isoforms, and distribution of the hyaluronan-binding protein RHAMM in adult and developing rat brain. J Comp. Neurol. 439:315-330.

18. Lynn BD, Li XB, Cattini PA, Nagy JI. (2001) Sequence, protein expression and extracellular-regulated kinase association of the hyaladherin RHAMM (receptor for hyaluronan mediated motility) in PC12 cells. Neurosci. Lett. 306:49-52.

19. Luo GX, Zhou XL, Li XB. (2000) Effect of nalaxone on left ventricular pressure during acute hypoxia in rats. The Journal of Medical Theory and Practice. 13:9-11.

20. Li XB, Zhu YC, Yao T. (1999) Identification of differential expressed genes in the kidney of SHR and WKY rats by mRNA differential display. Progress in Biochemistry and Biophysics, 1999, 26(6), 581-584.

21. Li XB, Zhao XS, Tian DZ, Zhu YC, Yao T. (1999) A new method for PCR products cloning. Progress in Biochemistry and Biophysics, 26(2), 187-189.