Department of Internal Medicine

National Taiwan University Hospital, Chinese Taipei

Clinical Assistant Professor

Email: chienyuanchen@ntu.edu.tw

Qualifications

1995 M.D., Taipei Medical College

Publications (selected)

1. Chou WC, Tang JL, Wu SJ, Tsay W, Yao M, Huang SY, Huang KC, Chen CY, Huang CF, Tien HF. Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations. Leukemia. 2007 May; 21(5): 998-1004.
2. Chen CY, Lin LI, Tang JL, Ko BS, Tsay W, Chou WC, Yao M, Wu SJ, Tseng MH, Tien HF. RUNX1 gene mutation in primary myelodysplastic syndrome - the mutation can be detected early at diagnosis or acquired during disease progression and is associated with poor outcome. Br J Haematol. 2007 Nov; 139 (3): 405-14.
3. Hou HA, Chou WC, Lin LI, Tang JL, Tseng MH, Huang CF, Yao M, Chen CY, Tsay W, Tien HF. Expression of angiopoietins and vascular endothelial growth factors and their clinical significance in acute myeloid leukemia. Leuk Res. 2008 Jun; 32(6): 904-12.
4. Hou HA, Chou WC, Lin LI, Chen CY, Tang JL, Tseng MH, Huang CF, Chiou RJ, Lee FY, Liu MC, Tien HF. Characterization of acute myeloid leukemia with PTPN11 mutation: the mutation is closely associated with NPM1 mutation but inversely related to FLT3/ITD. Leukemia. 2008 May; 22(5): 1075-8.
5. Huang TC, Ko BS, Tang JL, Hsu C, Chen CY, Tsay W, Huang SY, Yao M, Chen YC, Shen MC, Wang CH, Tien HF. Comparison of hypoplastic myelodysplastic syndrome (MDS) with normo-/hypercellular MDS by International Prognostic Scoring System, cytogenetic and genetic studies. Leukemia. 2008 Mar; 22(3): 544-50
6. Wu SJ, Chen CY, Su IJ, Tang JL, Chou WC, Ko BS, Huang SY, Yao M, Tsay W, Chen YC, Wang CH, Tien HF. Clinical Characteristics and Treatment Response of Hodgkin's Lymphoma in Taiwan. J Formos Med Assoc. 2008 Jan; 107(1): 4-12.
7. Chen CY, Tai CH, Tsay Woei, Chen PY, Tien HF. Prediction of Fatal Intracranial Hemorrhage In Patients with Acute Myeloid leukemia. Annals of Oncology 2009; 20(6): 1100-4.
8. Liu TY, Chen CY, Tien HF, Lin CW. Loss of CD7, independent of galectin-3expression, implies a worse prognosis in adult T-cell leukaemia/lymphoma. Histopathology. 2009; 54(2): 214-20.
9. Chou WC, Chen CY, Hou HA, Lin LI, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Tseng MH, Huang CF, Tien HF. Acute myeloid leukemia bearing t(7;11)(p15;p15) is a distinct cytogenetic entity with poor outcome and a distinct mutation profile: comparative analysis of 493 adult patients. Leukemia. 2009 23(7): 1303-10.
10. Hou HA, Lin LI, Chen CY, Tien HF. Reply to 'Heterogeneity within AML with CEBPA mutations; only CEBPA double mutations, but not single CEBPA mutations are associated with favorable prognosis'. Br J Cancer. 2009 101(4): 738-40.
11. Tang JL, Hou HA, Chen CY, Liu CY, Chou WC, Tseng MH, Huang CF, Lee FY, Liu MC, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Lin LI, Tien HF. AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations. Blood. 2009 Dec 17; 114(26): 5352-61.
12. Chen CY, Tsay W, Tang JL, Tien HF, Chen YC, Chang SC, Hsueh PR. Epidemiology of bloodstream infections in patients with haematological malignancies with and without neutropenia. Epidemiol Infect. 2010 Jul; 138(7): 1044-51.
13. Chou WC, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Chang YC, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF. Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation. Blood. 2010 Apr 8; 115(14): 2749-54.
14. Hou HA, Huang TC, Lin LI, Liu CY, Chen CY, Chou WC, Tang JL, Tseng MH, Huang CF, Chiang YC, Lee FY, Liu MC, Yao M, Huang SY, Ko BS, Hsu SC, Wu SJ, Tsay W, Chen YC, Tien HF. WT1 mutation in 470 adult patients with acute myeloid leukemia: stability during disease evolution and implication of its incorporation into a survival scoring system. Blood. 2010 Jun 24; 115(25): 5222-31.
15. Chou WC, Huang HH, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, Ko BS, Wu SJ, Huang SY, Hsu SC, Chen YC, Huang YN, Chang YC, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF. Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations. Blood. 2010 Nov 18; 116(20): 4086-94.
16. Chou WC, Hou HA, Liu CY, Chen CY, Lin LI, Huang YN, Chao YC, Hsu CA, Huang CF, Tien HF. Sensitive measurement of quantity dynamics of FLT3 internal tandem duplication at early time points provides prognostic information. Ann Oncol. 2011 Mar; 22(3): 696-704.
17. Chou WC, Lei WC, Ko BS, Hou HA, Chen CY, Tang JL, Yao M, Tsay W, Wu SJ, Huang SY, Hsu SC, Chen YC, Chang YC, Kuo KT, Lee FY, Liu MC, Liu CW, Tseng MH, Huang CF, Tien HF. The prognostic impact and stability of Isocitrate dehydrogenase 2 mutation in adult patients with acute myeloid leukemia. Leukemia. 2011 Feb; 25(2): 246-53.
18. Chen CY, Sheng WH, Lai CC, Liao CH, Huang YT, Tsay W, Huang SY, Tang JL, Tien HF, Hsueh PR. Mycobacterial infections in adult patients with hematological malignancy. Eur J Clin Microbiol Infect Dis. 2011 Sep 7.
19. Chen CY, Sheng WH, Cheng A, Tsay W, Huang SY, Tang JL, Chen YC, Wang JY, Tien HF, Chang SC. Clinical characteristics and outcomes of Mycobacterium tuberculosis disease in adult patients with hematological malignancies. BMC Infect Dis. 2011 Nov 23; 11: 324.
20. Chen CY, Huang SY, Tsay W, Yao M, Tang JL, Ko BS, Chou WC, Tien HF, Hsueh PR. Clinical characteristics of candidaemia in adults with haematological malignancy, and antimicrobial susceptibilities of the isolates at a medical centre in Taiwan, 2001-2010. Int J Antimicrob Agents. 2012 Sep 21.
21. Wu SJ, Kuo YY, Hou HA, Li LY, Tseng MH, Huang CF, Lee FY, Liu MC, Liu CW, Lin CT, Chen CY, Chou WC, Yao M, Huang SY, Ko BS, Tang JL, Tsay W, Tien HF. The clinical implication of SRSF2 mutation in patients with myelodysplastic syndrome and its stability during disease evolution. Blood. 2012 Oct 11; 120(15): 3106-11.
22. Chen CY, Tai CH, Cheng A, Wu HC, Tsay W, Liu JH, Chen PY, Huang SY, Yao M, Tang JL, Tien HF. Intracranial hemorrhage in adult patients with hematological malignancies. BMC Med. 2012 Aug 29; 10:97
23. Lai CC, Tan CK, Cheng A, Chung KP, Chen CY, Liao CH, Huang YT, Hsueh PR. Nontuberculous mycobacterial infections in cancer patients in a medical center in Taiwan, 2005-2008. Diagn Microbiol Infect Dis. 2012 Feb;72(2): 161-5.

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