University of Arizona, USA

Assistant Professor

Email: mherbst1@email.arizona.edu

Qualifications

2006 Ph.D., University of Texas Medical Branch, Experimental Pathology and Vaccine Development

2001 B.S., Colorado Mesa University, Biology

Publications (Selected)

1. Herbst, Melissa M., Prescott, J., Palmer, AD., and T. Schountz*. 2002. Sequence and Expression Analysis of Deer Mouse Interferon-gamma, Interleukin 10, Tumor Necrosis Factor and Lymphotoxin-alpha. Cytokine. 17: 203-13.
2. Herbst, Melissa M. and Richard B. Pyles*. 2003. Immunostimulatory CpG Treatment for Genital HSV-2. Infections. J Antimicrob Chemother. 52: 887-9. PMID: 14585849
3. Green, R., M.M. Herbst, and T. Schountz*. 2004. Genomic Organization of Deer Mouse (Peromyscus maniculatus) Tumor Necrosis Factor. Bios. 75: 12-17.
4. Herbst-Kralovetz, Melissa M. and R.B. Pyles*. 2006. Toll-like Receptors, Innate Immunity and Herpes Simplex. Virus Pathogenesis. Herpes. 13:37-41. PMID: 16895653
5. Herbst-Kralovetz, Melissa M. and Richard B. Pyles*. 2006. Quantification of Poly I:C-Mediated Protection against Genital Herpes Simplex Virus Type 2 Infection. Journal of Virology. 80: 9988-9997. PMID: 17005677
6. Herbst-Kralovetz, Melissa M. Greene, S., Quayle, A.J., and R.B. Pyles*. 2008. Quantification of Toll-like. Receptor Expression and Responsiveness in the Human Female Lower Genital Tract Epithelia. American Journal of Reproductive Immunology. 59: 212-24. PMID: 18201283
7. Hjelm, B., Berta, A., Nickerson, C., Arntzen, C. and M.M. Herbst-Kralovetz*. 2010. Development and Characterization of a 3-D Model of Human Vaginal Epithelia for Microbicide Screening. Biology of Reproduction. 82: 617-627. PMID: 20007410
8. Barrila, J., Radtke, A., Crabbe, A., Sarker, S., Herbst-Kralovetz, M., Ott, M and C.A. Nickerson*. 2010.
9. Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions. Nature Reviews Microbiology. 11:791-801. PMID: 20948552
10. Herbst-Kralovetz, Melissa M, Mason, HS* and Q. Chen. 2010. Norwalk Virus-like Particles as Vaccines. Expert Reviews In Vaccines. 9:299-307. PMID: 1020218858
11. Velasquez, L., Hjelm, B., Arntzen, C. and M.M. Herbst-Kralovetz*. 2010. An intranasally delivered TLR7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles. Clinical Vaccine Immunology. Epub ahead of print (Dec. 2010). PMID: 20962211
12. Velasquez, L., Shira, S., Berta, AN., Kilbourne, J., Medi, BM., Tizard, I., Ni, Y., Arntzen, C. and M.M. Herbst-Kralovetz*. Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine. Vaccine. 2011 Jul 18; 29 (32): 5221-31. PMID: 21640778
13. Mason HS and M. Herbst-Kralovetz. Plant-derived antigens as mucosal vaccines. In: Current Topics in Microbiology and Immunology; Mucosal Vaccines: Modern Concepts, Strategies, and Challenges (Kozlowski, PA, ed.) Curr Top Microbiol Immunol. 2011 Aug 3. [Epub ahead of print] PMID: 21811930
14. Phoolcharoen, W., Dye, J.M., Kilbourne, J., Piensook, K., Pratt, W.D., Arntzen, C.A., Mason, H., and M.M., Herbst-Kralovetz*. Ebola immune complex co-delivered with poly (I:C) protects mice against lethal Ebola challenge. Proc Natl Acad Sci U S A. 2011 Dec 20; 108 (51): 20695-700. PMID: 22143779
15. Radtke, AL and M.M. Herbst-Kralovetz*. Culturing and applications of rotating wall vessel bioreactor derived 3D epithelial cell models. J Vis Exp. 2012 Apr 3; (62). PMID: 22491366
16. Jackson, E. and M.M. Herbst-Kralovetz*. Intranasal vaccination with murabutide enhances humoral and mucosal immune responses to a virus-like particle vaccine. PLoS ONE. 2012; 7 (7): e41529. Epub 2012 Jul 25.
17. Radtke,A.L., A.J. Quayle, M.M. Herbst-Kralovetz*. Microbial products alter the expression of membraneassociated mucin and antimicrobial peptides in a 3-D human endocervical epithelial cell model. Biology of Reproduction, 2012. Oct. 10. Epub ahead of print. PMID: 23053434.
18. Herbst-Kralovetz, M.M.*, Radtke, A.L., et al. (2013) Lack of norovirus replication and histo-blood group antigen expression in three-dimensional intestinal epithelial cell cultures. Emerging Infectious Diseases in press.
19. McGowin CL, Radtke AL, Abraham K, Martin DH, Herbst-Kralovetz M. (2013) Mycoplasma genitalium infection activates cellular host defense and inflammation pathways in a 3-D human endocervical epithelial cell model. [Epub ahead of print]

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