Dr. Yunfeng Zhao
Department of Pharmacology, Toxicology & Neuroscience
LSU Health Sciences Center, Shreveport, Louisiana, USA
Associate Professor
Email: yzhao1@lsuhsc.edu
Qualifications
2000 Postdoc, University of Kentucky, USA
1997 Ph.D., Jilin University, China
1994 M.S., Jilin University, China
1991 B.S., Jilin University, China
Publications (Selected)
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Singleterry J, Sreedhar A, Zhao Y. Components of Cancer Metabolism and Therapeutic Interventions. Mitochondrion. Review. 17:50-5, 2014.
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Li W, Liu J, Jackson K, Shi R, Zhao Y. Sensitizing the therapeutic efficacy of taxol with shikonin in human breast cancer cells. PLoS One. 2014;9(4):e94079.
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Robbins D, Zhao Y. Manganese superoxide dismutase in cancer prevention. Antioxid Redox Signal. 20: 1628-45, 2014.
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Li W, Liu J, Zhao Y. PKM2 Inhibitor Shikonin Suppresses TPA-induced Mitochondrial Malfunction and Proliferation of Skin Epidermal JB6 Cells. Mol Carcinog. 53: 403-12, 2014.
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Li W, Zhao Y. Withaferin A Suppresses Tumor Promoter TPA-induced Decreases in IDH1 Activity and Mitochondrial Function in Skin Epidermal JB6 Cells. Cancer Sci. 104: 143-8, 2013.
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Robbins D, Ponville J, Morris K, Zhao Y. Involvement of PTEN in TPA-mediated p53-activation in mouse skin epidermal JB6 cells. FEBS Lett, 586: 4108-13, 2012.
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Robbins D, Wittwer JA, Codarin S, Circu M, Aw TK, Huang TT, VanRemmen H, Richardson A, Wang DB, Witt SN, Klein RL, Zhao Y. IDH1 Is Downregulated during Early Skin Tumorigenesis Which Can Be Inhibited by Overexpression of MnSOD. Cancer Sci. 103: 1429-33, 2012.
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Robbins D, Zhao Y. Oxidative Stress Induced by MnSOD-p53 Interaction: Pro- or Anti-tumorigenic? J Signal Transduct. 2012: 101465, 2011. Review.
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Robbins D, Zhao Y. New Aspects of Mitochondrial Uncoupling Proteins (UCPs) and Their Roles in Tumorigenesis. Int J Mol Sci. 12: 5285-5293, 2011. Review.
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Wittwer JA, Robbins D, Wang F, Codarin S, Shen X, Kevil C, Huang TT, Remmen H, Richardson A, Zhao Y. Enhancing Mitochondrial Respiration Suppresses Tumor Promoter TPA Induced PKM2 Expression and Cell Transformation in Skin Epidermal JB6 Cells. Cancer Prev Res. 4: 1476-84, 2011
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Wang F, Liu J, Robbins D, Morris K, Sit A, Liu YY, Zhao Y. Mutant p53 exhibits trivial effects on mitochondrial functions which can be reactivated by ellipticine in lymphoma cells. Apoptosis. 16: 301-10, 2011.
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Wang F, Fu X, Chen X, Chen X, Zhao Y. Mitochondrial uncoupling inhibits p53 mitochondrial translocation in TPA-challenged skin epidermal JB6 cells. PLoS One. 5: e13459, 2010.
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Liu J, St. Clair DK, Gu X, Zhao Y. Blocking mitochondrial permeability transition prevents p53 mitochondrial translocation during skin tumor promotion. FEBS Lett. 582: 1319-1324, 2008.
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Zhao Y, Chaiswing, L, Bakthavatchalu V, Oberley TD, St. Clair DK. Ras mutation promotes p53 activation and apoptosis of skin keratinocytes. Carcinogenesis. 27: 1692-1698, 2006.
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Zhao Y, Chaiswing L, Velez JM, Batinic-Haberle I, Colburn NH, Oberley TD, St. Clair DK. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein - manganese superoxide dismutase. Cancer Res. 65:3745-3750, 2005.
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Zhao Y, Chaiswing L, Oberley TD, Batinic-Haberle I, St. Clair W, Epstein CJ, St. Clair D. A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. Cancer Res. 65:1401-1405, 2005.
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Zhao Y, Oberley TD, Chaiswing L, Lin SM, Epstein CJ, Huang TT, St Clair DK. Manganese superoxide dismutase deficiency enhances cell turnover via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene. 21:3836-3846, 2002.
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Zhao Y, Xue Y, Oberley TD, Kiningham KK, Lin SM, Yen HC, Majima H, Hines J, St. Clair DK. Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res. 61:6082-6088, 2001.
Profile Details
http://www.lsuhscshreveport.edu/departments/BasicScience/pharmacologytoxicologyandneuroscience/faculty/index
Last Updated: 2015-07-01