Biography

Dr. Paola Massari

Boston University School of Medicine

Section of Infectious Diseases, USA

Research Assistant Professor


Email: pmassari@bu.edu


Qualifications

1995 Ph.D., University of Napoli “Federico II” and Biocine-Chiron Vaccines, Siena, Italy, Advanced Biotechnology/Protein Engineering and Biopolymers Program

1990 LAUREA (M. Sc), University of Napoli “Federico II”, Italy, Biology


Publications(Selected)

  1. Sasso M. P., Confalone E.,Massari P. and Furia A. 1991. Studies on mammalian ribonuclease genes.Italian Journal of Biochemistry,vol. 40, supp. 1.
  2. Marchini A.,Massari P., Manetti R. and Olivieri R. 1994.Optimized condition for the fermentation ofH. pyloriand production of vacuolating toxin.FEMS Microbiol. Lett., 124, 55-60. [PMID: 8001770]
  3. Marchini A., D`Apolito M.,Massari P., Atzeni M., Copass M. and Olivieri R. 1995. Cyclodextrins for growth ofH. pyloriand production of vacuolating cytotoxin.Arch. Microbiol., 164, 290-293. [PMID: 7487335]
  4. Manetti R.,Massari P., Burroni D., De Bernard M., Marchini A., Olivieri R., Montecucco C., Rappuoli R. and Telford J.L. 1995.Helicobacter pyloricytotoxin: importance of native conformation for induction of neutralizing antibodies.Infect. Immun., 63 (11), 4476-4480. [PMID: 7591088] (PMCID: 173637
  5. Papini E., Gortari E., Satin B., De Bernard M., Telford J.L.,Massari P., Rappuoli R. and Montecucco C. 1996. Detection of V ATPase on the membrane of intracellular vacuoles induced by VacA ofHelicobacter pylori.J.Med. Microbiol.,45, 84-89. [PMID: 8683556]
  6. Lupetti P., Heuser J., Manetti R.,Massari P., Lanzavecchia S., Bellon P.L., Dallai R., Rappuoli R. and Telford J.L. 1996. Oligomeric and subunit structure of theHelicobacter pylorivacuolating cytotoxin.J.Cell. Biol.,133 (4), 801 - 807. [PMID: 8666665] (PMCID: 2120837)
  7. Manetti R.,Massari P., Marchetti M., Magagnoli C., Nuti S., Lupetti P., Ghiara P., Rappuoli R.and Telford J.L. 1997.Detoxification of theHelicobacter pyloricytotoxin.Infect. Immun., 65 (11), 4615 - 4619. [PMID: 9353041] (PMCID: 175662)
  8. Marchetti M., Rossi M., Giannelli V., Giuliani M. M., Pizza M. G., Censini S., Covacci A.,Massari P., Pagliaccia C., Manetti R., Telford J.L., Douce G., Dougan G., Rappuoli R. and Ghiara P. 1998. Protection againstHelicobacter pyloriinfection in mice by intragastric vaccination withH. pyloriis achieved using a non toxin mutant ofE. coliheat labile enterotoxin (LT) as adjuvant.Vaccine, 16 (1), 33-37. [PMID: 9607006]
  9. Massari P., Manetti R., Burroni D., Nuti S., Norais N., Rappuoli R. and Telford J.L. 1998. Binding of theHelicobacter pylorivacuolating cytotoxin to target cells.Infect. Immun., 66 (8), 3981-3984 [PMID: 9673292] (PMCID: 108470)
  10. Guarino A., Bisceglia M., Berni Canani R., Boccia M.C., Bruzzese E.,Massari P., Rappuoli R. and Telford J.L. 1998. Enterotoxic effect of vacuolating toxin produced byHelicobacter pyloriin CACO-2 cells.J. Infect. Dis., 178 (5), 1373-1378. [PMID: 9780258]
  11. Massari P., Ho Y. and Wetzler L.M. 2000.Neisseria meningitidisporin PorB interacts with mitochondria and protects from apoptosis.PNAS, 97, 9070-9075. [PMID: 10922061] (PMCID: 16823)
  12. Massari P., Henneke P., Ho Y., Latz E., Golenbock D. T. and Wetzler L. M. 2002. Immune stimulation by neisserial porins is TLR2 and MyD88-dependent.J. Immunol., 168:1533-1537. [PMID: 11823477]
  13. Massari P., King C. A., Ho A. Y. and Wetzler L. M. 2003. Neisserial PorB is translocated in the mitochondria of HeLa cells infected withN. meningitidisand protects cells from apoptosis.Cell Microbiol., Feb;5(2):99‑109. [PMID: 12580946]
  14. Tan W. Z.,Massari P., Wetzler L. M. and Colombini M. 2004. Bacterial channel inhibits apoptosis by permeabilizing the mitochondrial outer membrane.BIOPHYSICAL JOURNAL, 86 (1): 517A Part 2 Suppl. S Jan.
  15. Singleton T. E.,Massari P. and Wetzler L. M. 2005. Neisserial porin-induced dendritic cell activation is MyD88 and TLR2 dependent.J Immunol., Mar 15;174(6):3545‑50. [PMID: 15749891]
  16. Massari P., King C.A., MacLeod H. and Wetzler L.M. 2005. Improved purification of native meningococcal porin PorB and studies on its structure/function.Prot. Express. and Purif., 44, 136 - 146. [PMID: 16027004]
  17. Massari P., Visintin A., Gunawardana J., Halmen K. A., King C. A., Golenbock D. T. and Wetzler L. M.. 2006. Meningococcal porin PorB binds to TLR2 and requires TLR1 for signaling.J. Immunol., Feb; 176: 2373‑2380. [PMID: 16455995]
  18. Liu X., Wetzler L. M. andMassari P. 2008.The PorB porin from commensalNeisseria lactamicainduces Th1 and Th2 immune responses to ovalbumin in mice and is a potential immune adjuvant.Vaccine. Feb 6;26(6):786-96. [PMID: 18191311] (PMCID: 2259119)
  19. Follows S.A., Murlidharan J.,Massari P., Wetzler L. M. and Genco C. A. 2009.Neisseria gonorrhoeaeinfection protects human cervical epithelial cells from apoptosis via expression of host anti-apoptotic proteins.Infect. Immun., Sep; 77(9):3602-10 [PMID: 19546192] (PMCID: 2738021)
  20. Massari P., Gunawardana J., Liu X. and Wetzler L. M. 2010. Meningococcal porin PorB prevents cellular apoptosis in a TLR2- and NF-{kappa}B-independent manner.Infect. Immun. Mar;78 (3):994-1003. [PMID:20028813] (PMCID: 2825956)
  21. Vaughan A. T., Brackenbury L. S.,Massari P., Davenport V., Gorringe A., Heyderman R. S. and Williams N. A.J. Immunol., 2010.Neisseria lactamica Selectively Induces Mitogenic Proliferation of the Naive B Cell pool via Cell Surface Ig.2010 Sep 15;185(6):3652-60. [PMID: 20709949] (PMCID in process)
  22. Liu X., Wetzler L. M., Oliveira Nascimento L. andMassari P. 2010. Human airway epithelial cell responses to Neisseria lactamica and purified porin via TLR2-dependent signaling.Infect .Immun. Dec;78(12):5314-23.[PMID: 20937766] (PMCID:2981301)
  23. Liang Y.M, Elliot J., Noronha A.M., Liu X., Hetzel J., Wetzler L. M., Rarick M. D.,Massari P., Hasturk H., Kantarci A., Winter H., Farraye F. and Ganley-Leal L. M.2011.Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells.Clinical Immunol.Jan;138(1):33-40. PMID:20947433(PMCID in process)
  24. Arjunaraja S.,Massari P., Wetzler L.M., Lees A., Colino J. and C. M. Snapper. 2012.The nature of an in vivo anti-capsular polysaccharide response is markedly influenced by the composition and/or architecture of the bacterial subcapsular domain.J. Immunol. Jan 15;188(2):569-77 [PMID: 22156342] (PMCID: 3253264)
  25. Toussi D. N., Liu X. andMassari. P. The FomA Porin fromFusobacterium nucleatumIs a Toll-Like Receptor 2 Agonist with Immune Adjuvant Activity. 2012.Clin.Vaccine Immunol. Jul;19(7):1093-101. PMID: 22623652 (PMCID in process)


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