Dr. Zhiwei Huang
National University of Singapore,
Singapore
Email: biehzw@nus.edu.sg
Qualifications
1999 Ph.D., Nanyang Technological
University
1990 M.Sc., Fujian Normal
University
1987 B.Sc., Fujian Normal
University
Publications (selected)
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S Duraipandian, W Zheng, J Ng, Jeffrey
Low, A Ilanacheran, Z Huang*, In vivo diagnosis of cervical precancer using
Raman spectroscopy and genetic algorithm techniques, Analyst, DOI:
10.1039/c1an15296c, (2011).
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B Lin, M Bergholt, D Lau, Z Huang*,
Optical diagnosis of nasopharyngeal cancer using ultraviolet autofluorescence
excitation-emission matrix spectroscopy and parallel factor analysis, Analyst,
DOI: 10.1039/c1an15525c (2011).
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M Bergholt, W Zheng, Z Huang*,
Characterizing variability in in vivo Raman spectroscopic properties of
different anatomical sites of normal tissue in the oral cavity, Journal of
Raman Spectroscopy, DOI: 10.1002/jrs.3026 (2011).
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X Shao, W Zheng, Z Huang*, In vivo
diagnosis of colonic precancer and cancer using near-infrared autofluorescence
spectroscopy and biochemical modeling, Journal of Biomedical Optics, 16(6),
067005 (2011).
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M Bergholt, W Zheng, K Lin, K Ho, M
Teh, K Yeoh, J So, Z Huang*, Combining near-infrared-excited autofluorescence
and Raman spectroscopy improves in vivo diagnosis of gastric cancer, Biosensors
and Bioelectronics, 26, 4104-4110 (2011).
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M Bergholt, W Zheng, K Lin, K Ho, M
Teh, K Yeoh, J So, Z Huang*, Characterizing variability in in vivo Raman
spectra of different anatomical sites in the upper gastrointestinal tract
toward cancer detection, J Biomedical Optics, 16(3), 037003 (2011).
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N Lim, Z Hamed, C Yeow, C Chan, Z
Huang*, Early detection of biomolecular changes in disrupted porcine cartilage
using polarized Raman spectroscopy, Journal of Biomedical Optics, 16 (1),
017003 (2011).
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M Bergholt, W Zheng, K Lin, K Ho, M
Teh, K Yeoh, J So, Z Huang*, In vivo diagnosis of esophageal cancer using
imageguided Raman endoscopy and biomolecular modeling, Technology in Cancer
Research & Treatment, 10(2),103-112 (2011).
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M Bergholt, W Zheng, K Lin, K Ho, M
Teh, K Yeoh, J So, Z Huang*, In vivo diagnosis of gastric cancer using Raman
endoscopy and ant colony optimization techniques, Int J Cancer, 128(11),
2673-2680 (2011).
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X Shao, W Zheng, Z Huang*, Polarized
near-infrared autofluorescence imaging combined with near-infrared diffuse
reflectance imaging for improving colonic cancer detection, Optics Express, 18
(23), 24293-24300 (2010).
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M Bergholt, W Zheng, K Lin, K Ho, M
Teh, K Yeoh, J So, Z Huang*, Raman endoscopy for in vivo differentiation
between benign and malignant ulcers in the stomach, Analyst, 135 (12),
3162–3168 (2010).
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J Lin, F Lu, W Zheng, Z Huang*,
Annular aperture-detected coherent anti-Stokes Raman scattering microscopy for
high contrast vibrational imaging, Applied Physics Letters, 97 (8), 083701
(2010).
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C Yuen, W Zheng, Z Huang*, Low-level
detection of anti-cancer drug in blood plasma using microwave-treated
goldpolystyrene beads as surface-enhanced Raman scattering substrates,
Biosensors and Bioelectronics, 26, 580-584 (2010)
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Z Huang*, SK Teh, W Zheng, K Lin, KY
Ho, M Teh, KG Yeoh, In vivo detection of epithelial neoplasia in the stomach
using image-guided Raman endoscopy, Biosensors and Bioelectronics, 26, 383-389
(2010).
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K Lin, W Zheng, Z Huang*, Integrated
autofluorescence endoscopic imaging and point-wise spectroscopy for real-time
in vivo tissue measurements, Journal of Biomedical Optics, 15 (4), 040507
(2010).
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C Fang, F Lu, W Zheng, Z Huang*,
Triple-frequency symmetric subtraction scheme for nonresonant background
suppression in coherent anti-Stokes Raman scattering (CARS) microscopy, Optics
Express, 18 (15), 15714-15724 (2010).
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J Mo, W Zheng, Z Huang*, Fiber-optic
Raman probe couples ball lens for depth-selected Raman measurements of
epithelial tissue, Biomedical Optics Express, 1 (1), 17-30 (2010).
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Z Huang*, M Bergholt, W Zheng, K Lin,
K Ho, M Teh, K Yeoh, In vivo early diagnosis of gastric dysplasia using narrowband
image-guided Raman endoscopy, Journal of Biomedical Optics, 15 (3), 037017
(2010).
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J Lin, W Zheng, H Wang, Z Huang*,
Effects of scatterers’ sizes on near-field coherent anti-Stokes Raman
scattering under tightly focused radially and linearly polarized light
excitation, Optics Express, 18(10), 10888-10895 (2010).
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F Lu, W Zheng, J Lin, Z Huang*,
Integrated coherent anti-Stokes Raman scattering and multiphoton microscopy for
biomolecular imaging using spectral filtering of a femtosecond laser, Applied Physics
Letters, 96(14), 133701 (2010).
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H Li, W Zheng, Z Huang*, Rapid
near-infrared fluorescence excitation-emission matrix spectroscopy for
multifluorophores characterization using an acousto-optic tunable filter
technique, Journal of Biomedical Optics, 15 (2), 027010 (2010).
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SK Teh, W Zheng, KY Ho, M Teh, KG
Yeoh, Z Huang*, Near-infrared Raman spectroscopy for early diagnosis and typing
of adenocarcinoma in the stomach, British Journal of Surgery, 97(4), 550-557
(2010).
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SK Teh, W Zheng, KY Ho, M Teh, KG Yeoh,
Z Huang*, Near-infrared Raman spectroscopy for optical diagnosis in the
stomach: Identification of Helicobacter-pylori infection and intestinal
metaplasia, Int. J. Cancer, 126 (8), 1920-1927 (2010).
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C Yuen, W Zheng, Z Huang*,
Optimization of extinction efficiency of gold-coated polystyrene beads
substrates improves surface-enhanced Raman scattering effects by post-growth
microwave heating treatment, J. Raman Spectroscopy, 41 (4), 374-380 (2010).
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J Mo, W Zheng, Jeffrey Low, J Ng, A
Ilanacheran, Z Huang*, High wavenumber Raman spectroscopy for in vivo detection
of cervical dysplasia, Analytical Chemistry, 81, 8908-8915 (2009).
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J Lin, F Lu, H Wang, W Zheng, C
Sheppard, Z Huang*, Improved contrast radially polarized coherent anti-Stokes
Raman scattering microscopy using annular aperture detection, Applied Physics
Letters, Vol. 95, No. 13, 133703 (2009).
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F Lu, W Zheng, Z Huang*, Coherent
anti-Stokes Raman scattering microscopy using tightly focused radially
polarized light, Optics Letters, Vol.34, No.12, 1870-1872 (2009).
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Z Huang*, SK Teh, W Zheng, J Mo, K
Lin, X Shao, KY Ho, M Teh, KG Yeoh, Integrated Raman spectroscopy and trimodal
wide-field imaging techniques for real-time in vivo tissue Raman measurements
at endoscopy, Optics Letters, Vol.34, No.6, 758-760 (2009).
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J Lin, H Wang, W Zheng, F Lu, C
Sheppard, Z Huang*, Numerical study of effects of light polarization, scatterer
sizes and orientations on near-field coherent anti-Stokes Raman scattering
microscopy, Optics Express, 17 (4), 2423-2434 (2009).
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SK Teh, W Zheng, David P Lau, Z
Huang*, Spectroscopic diagnosis of laryngeal carcinoma using near-infrared
Raman spectroscopy and random recursive partitioning ensemble techniques,
Analyst, 134, 1232-1239 (2009).
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SK Teh, W Zheng, KY Ho, M Teh, KG
Yeoh, Z Huang*, Near-infrared Raman spectroscopy for gastric precancer
diagnosis, J. Raman Spectroscopy, 40, 908-914 (2009).
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F Lu, W Zheng, Z Huang*, Elliptically
polarized coherent anti-Stokes Raman scattering microscopy, Optics Letters, 33
(23), 2842-2844 (2008).
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F Lu, W Zheng, Z Huang*,
Phase-controlled polarization coherent anti-Stokes Raman scattering microscopy
for high sensitive and high contrast molecular imaging, Journal of the Optical
Society of America B, 25 (11), 1907-1913 (2008).
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C Yuen, W Zheng, Z Huang*, Improving
surface-enhanced Raman scattering effect using gold-coated hierarchical
polystyrene bead substrates modified with post-growth microwave treatment,
Journal of Biomedical Optics, 13 (6), 064040 (2008).
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C Yuen, W Zheng, and Z Huang*,
Surface-enhanced Raman scattering: principles, nanostructures, fabrications and
biomedical applications, J. Innovative Optical Health Sciences (JIOHS), 1 (2),
267-284 (2008).
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F. Jaillon, W. Zheng, and Z Huang*,
Half-ball lens couples a beveled fiber probe for depth-resolved spectroscopy:
Monte Carlo simulations, Appl. Opt. 47, 3152-3157 (2008).
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F Lu, W Zheng, and Z Huang*,
Heterodyne polarization coherent anti-Stokes Raman scattering microscopy,
Applied Physics Letters, 92 (12), 123901 (2008).
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F Lu, W Zheng, C Sheppard, Z Huang*,
Interferometric polarization coherent anti-Stokes Raman scattering microscopy,
Optics Letters, 33(6), 602-604 (2008).
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F Jaillon W Zheng, Z Huang*, Beveled
fiber-optic probe couples a ball lens for improving depth-resolved fluorescence
measurements of layered tissue: Monte Carlo Simulations, Phys. Med. Biol. 53,
937-951 (2008).
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SK Teh, W Zheng, KY Ho, M Teh, KG
Yeoh, Z Huang*, Diagnostic potential of near-infrared Raman spectroscopy in the
stomach: differentiating dysplasia from normal tissue. British Journal of
Cancer, 98, 457-465 (2008).
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SK Teh, W Zheng, KY Ho, M Teh, KG
Yeoh, Z Huang*, Diagnosis of gastric cancer using near-infrared Raman
spectroscopy and classification and regression tree techniques, Journal of
Biomedical Optics, 13 (3), 034013 (2008).
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E Widjaja, W Zheng and Z Huang*,
Classification of colonic tissues using near-infrared Raman spectroscopy and
support vector machines. Int. J. Oncology, 32: 653-662 (2008).