Dr. Jiyan Ma

Ohio State University, USA

Email: ma.131@osu.edu

Qualifications

1997 Ph.D., University of Illinois at Chicago
1990 Master of Medicine, Shanghai Medical University

1987 Bachelor of Medicine, Shanghai Medical University

Publications (Selected)

1. Ma, J. and Colley, K. J. (1996) A disulfide-bonded dimer of the Golgi b-galactoside a 2, 6-sialyltransferase is catalytically inactive yet still retain the ability to bind galactose. J. Biol. Chem. 271, 7758-7766.
2. Ma, J., Qian, R., Rausa, F. M., Colley, K. J. (1997) Two naturally occurring a2,6-sialyltransferase forms with a single amino acid change in the catalytic domain differ in their catalytic activity and proteolytic processing. J. Biol. Chem. 272, 672-679.
3. Ma, J., Simonovic, M., Qian, R., Colley, K. J., (1999) Sialyltransferase isoforms are phosphorylated in the Cis-medial Golgi on serine and threonine residues in their luminal sequences. J. Biol. Chem. 274, 8046-8052.
4. Chen, C., Ma, J., Lazic, A., Backovic, M., Colley, K. J. (2000) Formation of insoluble oligomers correlates with ST6Gal stable localization in the Golgi. J. Biol. Chem. 275, 13819-13826.
5. Ma. J. and Lindquist, S. (1999) De novo generation of a PrPSc-like conformation in living cells. Nat. Cell Biol. 1, 358-361.
6. Ma, J. and Lindquist, S. (2001) Wild-type PrP and a mutant associated with prion disease are subject to retrograde transport and proteasome degradation. Proc. Natl. Acad. Sci. USA. 98: 14955-60.
7. Ma, J. and Lindquist, S. (2002) Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science, 298(5599): 1785-8.
8. Ma, J., Wollmann, R., Lindquist, S. (2002) Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science, 298(5599): 1781-5.
9. Wang, X., Wang, F., Sy, MS., and Ma, J. (2005) Calpain and other cytosolic proteases can contribute to the degradation of retro-translocated prion protein in the cytosol. J. Biol. Chem. 280, 317-325.
10. Wang X., Thomas B., Sachdeva R., Arterburn L., Frye L., Hatcher P. G., Cornwell D. G., Ma J. (2006) Mechanism of quinone toxicity involving arylation and induction of ER stress. Proc. Natl. Acad. Sci. USA. 103: 3604-3609.
11. Wang X., Wang F., Arterburn L. Wollmann R., Ma J. (2006) The interaction between cytoplasmic PrP and the hydrophobic lipid core of membrane correlates with neurotoxicity. J. Biol. Chem. 281, 13478-13484.
12. Wang, F., Yang, F., Hu, Y., Wang, X., Wang, X., Jin, C., Ma, J. (2007) Lipid interaction converts prion protein to a PrPSc-like proteinase K resistant conformation under physiological conditions. Biochemistry 46(23): 7045-7053.
13. Wang, X., Bowers, S., Wang, F., Pu, X., Nelson, R. J., Ma, J. (2009) Cytoplasmic prion protein induces forebrain neurotoxicity. Biochimica et Biophysica Acta-Molecular Basis of Disease. 1792:555-563.
14. Wang, F., Wang, X., Yuan, C., Ma, J. (2010) Generating a Prion with Bacterially Expressed Recombinant Prion Protein. Science, 327: 1132-1135.
15. Faas, H., Jackson, W.S., Borkowski, A., Wang, X., Ma, J., Lindquist, S., Jasanoff, A. (2010) Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein. NeuroImage. 49: 2607-2617.
16. Wang, F., Yin S., Wang, X., Zha, L., Sy, M., Ma, J. (2010) Role of the highly conserved middle region of PrP in PrP-lipid interaction. Biochemistry 49: 8169-8176.
17. Wang N, Wang Y, Yu G, Yuan C, Ma J. (2011) Quinoprotein adducts accumulate in the substantia nigra of aged rats and correlate with dopamine-induced toxicity in SH-SY5Y cells. Neurochem Res. 36(11): 2169-2175.
18. Wang, F., Wang, X., Ma, J. (2011) Conversion of bacterially expressed recombinant prion protein. Methods 53 (3): 208-213.
19. Piro JR, Wang F, Walsh DJ, Rees JR, Ma J, Supattapone S. (2011) Seeding specificity and ultrastructural characteristics of infectious recombinant prions. Biochemistry 50(33): 7111-7116.
20. Wang F, Zhang Z, Wang X, Li J, Zha L, Yuan C, Weissmann C, Ma J. (2012) Genetic informational RNA is not required for recombinant prion infectivity. J. Virol. 86(3): 1874-1876.
21. Ma J. (2012) The role of Cofactors in Prion Propagation and Infectivity. PLoS Pathogens, PLoS Pathog 8(4): e1002589.