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Dr. Meifeng Xu

University of Cincinnati Medical Center, USA

Email: Meifeng.xu@uc.edu


1995-1999 Ph.D., Biological Sciences, The Hong Kong Polytechnic University, Hong Kong, P. R. of China

1986-1989 M.Sc., Pharmacology, Suzhou Medical College, P. R. of China

1977-1982 M.D., Medicine, Suzhou Medical College, P. R. of China

Publications (Selected)

  1. Zuo S, Jones WK, Li H, He Z, Pasha Z, Yang Y, Wang YG, Fan GC, Ashraf M, Xu M. Paracrine Effect of Wnt11 Overexpressing Mesenchymal Stem Cells on Ischemic Injury. Stem Cells Dev. 2011 Apr 4. [Epub ahead of print], (PMID: 21463175).
  2. He Z, Li H, Zuo S, Pasha Z, Wang Y, Yang Y, Jiang W, Ashraf M, Xu M. Transduction of Wnt11 Promotes Mesenchymal Stem Cells Transdifferentiation into Cardiac Phenotypes.Stem Cells Dev. 2011 Feb 26. [Epub ahead of print], (PMID: 21231807).
  3. Dai B, Huang W, Xu M, Millard RW, Gao MH, Hammond HK, Menick DR, Ashraf M, Wang Y. Reduced Collagen Deposition in Infarcted Myocardium Facilitates Induced Pluripotent Stem Cells (iPSC) Engraftment and Angiomyogenesis for Improvement of Left Ventricular Function. JACC (accepted on June 29, 2011).
  4. Huang W, Wang T, Zhang D, Zhao T, Dai B, Ashraf A, Wang X, Xu M, Millard RW, Fan GC, Ashraf M, Yu XY, Wang YG. Mesenchymal Stem Cells Overexpressing CXCR4 Attenuate Remodeling of Post-myocardial Infarction by Releasing Matrix Metalloproteinase-9. Stem Cells Dev. 2011 Jun 14, [Epub ahead of print] (PMID: 21671800).
  5. Li H, Zuo S, Pasha Z, Yu B, He Z, Wang Y, Yang X, Ashraf M, Xu M. GATA-4 promotes myocardial transdifferentiation of mesenchymal stromal cells via up-regulating IGFBP-4. Cytotherapy. 2011; 13: 1057-1065, (PMID: 21846294).
  6. Li H, Zuo S, He Z, Yang Y, Pasha Z, Wang Y, Xu M. Paracrine Factors Released by GATA-4 Overexpressed Mesenchymal Stem Cells Increase Angiogenesis and Cell Survival. Am J Physiol Heart Circ Physiol. 299(6):H1772-81, 2010. (PMID: 20870802) (Citation=3).
  7. Huang W, Zhang D, Millard RW, Wang T, Zhao T, Fan GC, Ashraf A, Xu M, Ashraf M, Wang Y. Gene manipulated peritoneal cell patch repairs infarcted myocardium. J Mol Cell Cardiol. 2010; 48:702-12. (PMID: 19913551) (Citation=3).
  8. Wang X, Zhao T, Huang W, Wang T, Qian J, Xu M, Kranias EG, Wang Y, Fan GC. Hsp20-Engineered Mesenchymal Stem Cells Are Resistant to Oxidative Stress via Enhanced Activation of Akt and Increased Secretion of Growth Factors. Stem Cells 2009, 27: 3021 – 31. (PMID:  19816949) (Citation=12)
  9. Dai Y, Ashraf M, Zuo S, Uemera R, Dai YS, Pasha Z, Haider KhH, Wang Y, Li TY, Xu M. Mobilized bone marrow progenitor cells participate in post-ischemia myocardial repair via secretion of growth factors. J Mol Cell Cardiol. 2008; 44: 607-17. (PMID: 18221754) (Citation=13).
  10. Zhang D, Fan GC, Zhou X, Zhao T, Pasha Z, Xu M, Zhu Y, Ashraf M, Wang Y. Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium. J Mol Cell Cardiol. 2008; 44: 281-92. (PMID: 18201717) (Citation=61).
  11. Dai Y, Xu M*, Pasha Z, Wang Y, Ashraf M. HIF-1α induce VEGF expression by bone marrow stem cell responsible for cardiac protection. J Mol Cell Cardiol. 2007;42:1036-44. *Corresponding author. (PMID: 17498737) (Citation=47).
  12. Xu M, Uemura R, Ying Dai, Yi-Gang Wang, Ashraf M. In vitro and in vivo effects of bone marrow stem cells on cardiac structure and function. J Mol Cell Cardiol. 2007; 42:441-448. (PMID: 17187821) (Citation=81).
  13. Uemura R*, Xu M*, Ahmad N, Ashraf M. Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res. 2006; 98:1414-21. * contributed equally to this study (PMID: 16690882) (Citation=231).
  14. Wang Y, Haider KhH, Ahmad N, Xu M, Ge R, Ashraf M. Combining pharmacological mobilization with intramyocardial delivery of bone marrow cells over-expressing VEGF is more effective for cardiac repair. J Mol Cell Cardiol. 2006; 40:736-45. (PMID: 16603183) (Citation=69).
  15. Xu M, Wani M, Dai Y, Wang J, Yan M, Ashraf M. Differentiation of bone marrow stromal cells into cardiac phenotype requires intercellular communication with myocytes.Circulation. 110: 2658-65; 2004. (PMID: 15492307) (Citation=71).
  16. Kudo M, Wang Y, Wani MA, Xu M, Ayub A, Ashraf M. Implantation of bone marrow stem cells reduces the infarction and fibrosis in ischemic mouse heart. J Mol Cell Cardiol. 35:1113-9, 2003. (PMID: 12967634) (Citation=98).
  17. Xu M, Ashraf M. Melatonin protection against lethal myocyte injury induced by doxorubicin as reflected by effects on mitochondrial membrane potential. J Mol Cell Cardiol34: 75-79, 2002.  (PMID: 11812166) (Citation=22).
  18. Kudo M, Wang YG, Xu M, Ayub A, Ashraf M. Adenosine A1 receptor mediates late preconditioning via activation of PKCd signaling pathway. Am J Physiol Heart Circ Physiol 283: H296-H301; 2002. (PMID: 12063302) (Citation=37).
  19. Xu M, Wang Y, Ayub A, Ashraf M. Mitochondrial KATP channel activation reduces anoxic injury by restoring mitochondrial membrane potential. Am J Physiol Heart Circ Physiol281: H1295-H1303, 2001. (PMID: 11514300) (Citation=51).
  20. Xu M, He S, Tang PL, Qian ZM. Melatonin protects against cardiac toxicity. J Pineal Res. 31: 301-307, 2001. (PMID: 11703558) (Citation=19).
  21. Xu M, Wang YG, Hirai K, Ayub A, Ashraf M. Calcium preconditioning inhibits mitochondrial permeability transition and apoptosis. Am J Physiol Heart Circ Physiol. 280: H899-H908, 2001. (PMID: 11158992) (Citation=64).
  22. Xu M, Tang PL, Qian ZM, Ashraf M. Effects by doxorubicin on the myocardium are mediated by oxygen free radical. Life Sci. 68: 889-901, 2001. (PMID: 11213359) (Citation=53).
  23. Wang Y, Takashi E, Xu M, Ayub A, Ashraf M. Down-regulation of protein kinase C inhibits activation of mitochondrial KATP channels by diazoxide. Circulation 104: 85-90; 2001. (PMID: 11435343) (Citation=69).
  24. Wang Y, kudo M, Xu M, Ayub A, Ashraf M. Mitochondrial KATP channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. J Mol Cell Cardiol 33: 2037-2046; 2001. (PMID: 11708847) (Citation=65).
  25. Tang PL, Xu M, Qian ZM. Differential behavior of cell membranes towards iron-induced oxidative damage and the effects of melatonin. Biol Signals 6:291-300; 1997. (PMID: 9500668) (Citation=10).
  26. Qian ZM, Xu M, Tang PL. Superoxide dismutase does protect the cultured rat cardiac myocytes against hypoxia/reoxygenation injury. Free Rad Res 27:13-21; 1997. (PMID: 9269575) (Citation=11).
  27. Qian ZM, Xu M, Tang PL. Polysaccharide peptide (PSP) restores immune-suppression induced by cyclophosphamide in rats. Am J Chinese Med XXV (1): 27-35; 1997. (PMID: 9166995) (Citation=21).
  28. SZ Liu, Xu M. The protection of anisodamine (654-2) against the acute radiation damage in mouse. Acta Academiae Medicinae Suzhou 16 (6): 1054-1055; 1996.
  29. Xu M, Pan JX, Qian ZN, Gu ZL. Antiatherosclerosis effect and mechanism of jianyanling on quail. Acta Academiae Medicinae Suzhou 14 (6): 469-472; 1994.
  30. Xu M, Gu ZL, Qian ZN. The effects of PSP on the immunological function of rats. PSP International Symposium. P.132-136. November, 15-19, 1993.
  31. Xu M, Qian ZN, Gu ZL. Immune enhancement effect of polysaccharides peptide (PSP) in rats. Acta Academiae Medicine Suzhou 13 (4): 270-273; 1993.
  32. Xu M, Qian ZN, Gu ZL. Ligongfang and immune function. Chinese Traditional Patent Medicine 14(11): 43-44; 1992.
  33. Qian ZN, Xu M, Gu ZL. Pharmacological studies on Leaves of Apocynum Hendersonii (Hook-F) Woodson. Chinese Traditional Patent Medicine 13 (7): 27-32; 1991.
  34. Xu M, Wang DS, Chan XZ. Effects of superoxide dismutase on ischemia reperfusion injury in isolated working heart and cultured myocardial cells of rats. Acta Pharma.Sinica11: 324-328; 1990. (PMID: 2104486).
  35. Wang DS, Xu M, Chan XZ. Study of pharmacodynamics and adverse reaction of superoxide dismutase. Modern Applied Pharmacy 6(4): 1-6; 1989.