Dr. Boris Z. Simkhovich

Heart Institute

Good Samaritan Hospital, USA

Email: simkhovi@usc.edu

Qualifications

1988 Doctor of Medical Sciences (Cardiovascular Pharmacology and Pathophysiology), Institute for General Pathology and Pathophysiology, Academy of Medical Sciences, Moscow, USSR

1976 Research Fellowship (Biochemistry and Molecular Biology), Institute for Medical and Biological Chemistry, Academy of Medical Sciences, Moscow, USSR

1971– 1974 Ph.D. in Biochemistry, Riga Medical School, Riga, Latvia

1965-1971 Resident, Internal Medicine, Riga Medical School, Riga, Latvia

1965-1971 M.D., Riga Medical School, Riga, Latvia

Publications (Selected)

1. Simkhovich BZ, Zamaraeva TV, Zelchan GI, Lukevics E, Mazurov VI: Effect of silatranes on collagen biosynthesis in cartilaginous tissue of chick embryos. Biokhimiia, 42:1128-1132, 1977.
2. Simkhovich BZ, Slutski LI, Dombrovskaya LE, Gilev AP, Zelchan GI, Lukevics E: Effect of silicon organic compounds on protein synthesis in the granulation fibrous tissue. Bulleten Eksperimentalnoij Biologii i Meditsini, 87:153-155, 1978.
3. Simkhovich BZ: Adenylate cyclase activity in Ehrlich ascites carcinoma cells in vitro. Voprosy Meditsinskoij Khimii, 24:768-774, 1978.
4. Slutski LI, Simkhovich BZ: Molecular heterogeneity of collagen.(Review).Uspekhi Sovremenoij Biologii, 89:58-73, 1980
5. Simkhovich BZ, Selina AV: Effect of cyclic adenosine-3,5-monophosphate and its dibutyryl analoq on the biosynthesis of macromolecules in actively proliferating cells. Bulleten Eksperimentalnoij Biologii i Meditsini, 90:320-322, 1980.
6. Simkhovich BZ, Slutski LI: Molecular heterogeneity of  collagen from skin of rats in early postnatal period. Voprosy Metitsinskoij Khimii, 28:110-114, 1982.
7. Nagobad VY, Simkhovich BZ, Parinov VY, Gilev AP: Furagin and Furadonin excretion in patients with chronic pyelonephritis. Urologiia i Nefrologiia, 6:49-52, 1982.
8. Simkhovich BZ, Kimenis AA: The mechanism of action of cardiovascular drugs- calcium antagonists. (Review). Khimiko-Farmacevticheskij Zhurnal, 2:134-147, 1984.
9. Velena AH, Dubur GJ, Vitolina RO, Kimenis AA, Selga MJ, Zarinsh GV, Narusevicius EV, Macianskiene RA, Gendvilene VI, Simkhovich BZ: Effect of ryodipine on electromechanical parameters of heart and vessels, cAMP phosphodiesteraseactivity and swelling-contraction cycle of mitochondria. Arzneimittel-Forschung (Drug Research), 35:907-914, 1985.
10. Simkhovich BZ, Meirena DV, Hagi HB, Kalvins IJ, Lukevics E. Influence of a new structural analoq of gamma-butyrobetaine- 3-(2.2.2-trimethylhydrazinium) propionate on carnitine-dependent fatty acids oxidation and some indexes of energy metabolism in myocardium. Voprosy Meditsinskoij Khimii, 32:72-76, 1986.
11. Odinec AG, Simkhovich BZ, Kimenis AA. Pharmacological effects and mechanism of action of 1,4-dihydropyridine derivatives on cardiovascular system. (Review). Khimiko-Farmacevticheskij Zhurnal, 12:1443-1451, 1986
12. Simkhovich BZ, Meirena DV, Hagi HB, Kalvins IJ, Lukevics E. Biochemical characterization of the antiischemic effects of a new structural analoq of gamma-butyribetaine, 3-(2,2,2-trimethylhydrazinium) propionate. Farmakologiia i Toksikologiia, 50:100-104, 1987.
13. Simkhovich BZ, Vitolina RO, Stivrina MI, Shutenko ZV, Meirena DV, Kimenis AA, Kalvins IJ, Lukevics E: Prevention of ischemic myocardium damage by reduction in intracellular free carnitine concentration. Kardiologiia, 27:85-88, 1987.
14. Simkhovich BZ, Shutenko ZV, Meirena DV, Khagi KB, Mezapuke RJ, Molodchina TN, Kalvins IJ, Lukevics E: 3-(2.2.2-Trimethylhydrazinium) propionate (THP) a novel gamma-butyrobetaine hydroxylase inhibitor with cardioprotective properties. Biochem Pharmacol, 37:195-202, 1988.
15. Simkhovich BZ, Meirena DV, Shutenko ZV, Hagi HB, Briede JL, Kalvins LJ, Lukevics E: Effect of D,L-carnitine and 3-(2,2,2-trimethylhydrazinium) propionate, an inhibitor of gamma-butyrobetaine hydroxylase,on isoproterenol induced impairments in myocardium metabolism. Voprosy Meditsinskoij Khimii, 34:30-34, 1988.
16. Simkhovich BZ, Mezapuke RJ, Dubur GJ: Study of biochemical effects of riodipine (foridone) a new calcium antagonist, 1,4- dihydropyridine derivative.Farmakologiia i Toksikologiia, 51:30-34, 1988.
17. Kagan TI, Lidak MY, Meirena DV, Simkhovich BZ: Search of antitumor agents among synthetic polycations. (Review). Khimiko-Farmacevticheskij Zhurnal, 6:646-656, 1988
18. Shutenko ZV, Simkhovich BZ, Meirena DV, Kalvins IJ, Lukevics E: Regulation of carnitine-dependent metabolism of fatty acids in rat myocardium using 3-(2,2,2-trimethyl hydrazinium) propionate. Voprosy Meditsinskoij Khimii, 35:59-64, 1989.
19. Simkhovich BZ, Meirena DV, Khagi KB, Freimanis YF: Effect of doprostone on fatty acid metabolism disturbances in therat heart caused by adrenergic stimuli. Farmakologiia i Toksikologiia, 52:24-27, 1989.
20. Simkhovich BZ, Briede YL, Ozola RA, Meirena DV, Kalvinsh IY, Lukevits EY: Effect of mildronate on the rat heart contractility impairment induced by excess free fatty acids and ischemia. Farmakologiia i Toksikologiia, 53:27-29, 1990.
21. Kagan TI, Simkhovich BZ, Kalvins IJ, Lukevics EJ: Effect of the inhibitor of carnitine-dependent metabolism mildronate on fatty acid oxidation in liver mitochondria of intact rats. Voprosy Meditsinskoj Khimii, 37:44-46, 1991.
22. Shutenko ZV, Priyedena IA, Mezhapuke RY, Simkhovich BZ, Kalvinsh IJ, Lukevits EY: Effect of a carnitine biosynthesis inhibitor mildronate on some parameters of lipid metabolism in rats. Farmakologiia i Toksikologiia, 54:55-56, 1991.
23. Simkhovich BZ, Meirena DV, Khagi KB, Shutenko ZV, Molodchina TN, Kalvinsh IJ, Lukevich EJ: Effect of mildronate on carnitine-dependent and carnitine-independent ketogenesis in rats. Farmakologiia i Toksikologiia, 54:41-42, 1991.
24. Simkhovich BZ, Hale SL, Kloner RA: Effect of ischemic preconditioning on carnitine-linked metabolism in the rabbit heart. Coronary Artery Disease, 3:141-147, 1992.
25. Simkhovich BZ, Hale SL, Ovize M, Przyklenk K, Kloner RA: Ischemic preconditioning and long-chain acyl carnitine in the canine heart. Coronary Artery Disease, 4:387-392, 1993.
26. Bauer B, Simkhovich BZ, Kloner RA, Przyklenk K: Does preconditioning protect the coronary vasculature from subsequent ischemia/reperfusion injury? Circulation, 88:659-671, 1993.
27. Simkhovich BZ, Kloner RA, Alker KJ, Giaconi J: The time course of direct cardiotoxic effects of high cocaine concentration in isolated rabbit hearts. J. Cardiovasc Pharmacol, 23:509-516, 1994.
28. Przyklenk K, Simkhovich BZ, Bauer B, Kloner RA: Deterioration in myocardial blood flow during relief of sustained ischemia is not explained by release of endothelin. Basic Res Cardiol. 89:260-269, 1994.
29. Przyklenk K, Aoki A, Bellows S, Kleindienst D, Zubiate P , Hale SL, Simkhovich BZ, Kloner RA, Kay GL: Stunned myocardium following prolonged cardiopulmonary bypass: Effect of warm versus cold cardioplegia in the canine model. J Card Surg. 9:506-516, 1994.
30. Bellows SD, Hale SL, Simkhovich BZ, Kay GL, Kloner RA: Do antioxidant vitamins reduce infarct size following acute myocardial ischemia/reperfusion. Cardiovascular Drugs and Therapy, 9:117-123, 1995.
31. Przyklenk K, Sussman MA, Simkhovich BZ, Kloner RA: Does ischemic preconditioning trigger translocation of protein kinase C. Circulation, 92:1546-1557, 1995.
32. Simkhovich BZ, Whittaker P, Przyklenk K, Kloner RA: Transient pre-ischemic acidosis protects the isolated rabbit heart subjected to 30 minutes, but not 60 minutes, of global ischemia. Basic Research in Card, 90:397-403, 1995.
33. Simkhovich BZ, Przyklenk K, Hale SL, Patterson M, Kloner RA: Diretct evidence that ischemic preconditioning does not cause protein kinase C translocation in rabbit heart. Cardiovascular Research, 32:1064-1070, 1996.
34. Kamlot A, Bellows SD, Simkhovich BZ, Hale SL, Aoki A, Kloner RA, Kay GL: Is warm retrograde blood cardioplegia better than cold for myocardial protection. The Annals of Thor Sur, 63:98-104, 1997.
35. Simkhovich BZ, Przyklenk K, Kloner RA: Role of protein kinase C as a cellular mediator of ischemic preconsitioning: a critical review. Cardiovasc Res, 40:9-22, 1998.
36. Simkhovich BZ, Kloner RA, Przyklenk K: Temporal changes in the subcellular distribution of protein linase C in rabbit heart during global ischemia. Basic Res Cardiol, 93:122-126, 1998.
37. Przyklenk K, Simkhovich BZ, Bauer B, Hata K, Zhao L, Elliott GT, Kloner RA: Cellular mechanisms of infarct size reduction with ischemic preconditionin. Ann NY Acad Sci, 874:192-210, 1999.
38. Bauer B, Simkhovich BZ, Kloner RA, Przyklenk K: Preconditioning-induced cardioprotection and release of second messenger inositol (1,4,5)-triphosphate are abolished by neomycin in rabbit heart. Bas Res Cardiol, 94:31-40, 1999..
39. Gysembergh A, Simkhovich BZ, Kloner RA, Przyklenk K: p38 MAPCK activity is no increased early during sustained coronary occlusion in preconditioned versus control rabbit heart. J Mol Cell Cardiol, 33:681-690, 2001.
40. Simkhovich BZ, Abdishoo S, Poizat C, Hale SL, Kedes KH, Kloner RA: Gene activity changes in ischemically preconditioned rabbit heart: gene discovery array study. Heart Dis, 4:63-69, 2002.
41. Reffelmann T, Dow JS, Dai W, Hale SL, Simkhovich BZ, Kloner RA. Transplantation of neonatal cardiomyocytes after permanent coronary artery occlusion increases blood flow of infracted myocardium. J Mol Cell Cardiol, 25:607-613, 2003.
42. Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA: Brief episode of ischemia activates protective genetic program in rat heart: a gene chip study. Cardiovasc Res, 59:450-459, 2003.
43. Simkhovich BZ, Marjoram P, Poizat C, Kedes L, Kloner RA: Age-related changes of cardiac gene expression following myocardial ischemia/reperfusion. Arch Biochem Biophys, 420:268-278, 2003.
44. Przyklenk K, Li G, Simkhovich BZ, Kloner RA: Mechanisms of myocardial ischemic preconditioning are age-related: protein kinase C-e does not play a requisite role in old rabbits. J Appl Physiol 95:2563-2569, 2003.
45. Simkhovich BZ, Kloner RA, Poizat C, Marjoram P, Kedes LH: Gene expression profiling – a new approach in the study of myocardial ischemia. Cardiovasc Pathol, 12:180-185, 2003.
46. Kedes L, Kloner R, Kong K, Poizat C, Simkhovich BZ, Iso T, Hamamori Y: New cellular and molecular approaches for the treatment of cardiac disease. Sem in Neph,; 24:437-440, 2004.
47. Simkhovich BZ, Hale SL, Kloner RA: Metabolic mechanism by which mild regional hypothermia preserves ischemic tissue. J Cardiovasc Pharmacol Therapeut, 9:83-90, 2004.
48. Dow J, Simkhovich BZ, Kedes L, Kloner RA: Washout of transplanted cells from the heart: A potential new hurdle for cell transplantation therapy. Cardiovasc Res, 67:301-307, 2005.
49. Kloner RA, Simkhovich BZ: Benefits of exercise prior to myocardial infarction. J Am Coll Cardiol, 45:939-940, 2005.
50. Sesti C, Simkhovich BZ, Kalvinsh I, Kloner RA. Mildronate, a novel fatty acid oxidation inhibitor and anti-anti-anginal agent, reduces myocardial infarct size independent of hemodynamics. J Cardiovasc Pharmacol, 2006, 47: 493-499.