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Biography


Prof. Jacob George

The Department of Cardiology

Tel Aviv University, Israel


E-mail: jgeorge@bezeqint.net


Qualifications


1998   Internal Medicine Residency (passage of phase B exams in 1997, Cum Laude) 

1989   M.D., Technion Medical School, Haifa, Cum Laude   

1986   B.Sc., Technion Medical School, Haifa


Publications (Selected)

  1. Y. Beigel, J. George, L. Leibovici, A. Mattityahu, S. Sclarovsky, L. Blieden. Coronary risk factors in children of parents with premature coronary heart disease.  Acta Pediatrica  82: 162-165, 1993.
  2. Y. Levy, J. George, Y. Shoenfeld. The occurrence of thromboembolic events following airplane flights-’the economy class syndrome’. Isr J Med Sci  331: 621-23, 1995.
  3. L. Leibovitch, J. George, Y. Levy, R.  Bakimer, Y. Shoenfeld. Anti actin antibodies determination in sera from patients with autoimmune, liver diseases and patients with carcinomas by ELISA assay. Immunology Letters  48: 129-132, 1995.
  4. Y. Levy Y, J. George, M. Hojnik, M. Ehrenfeld, M. Lorber, S. Bombaridieri, Y. Shoenfeld.  Comparison of clinical and laboratory parameters in patients with SLE between Israelis versus Europeans. Isr J Med Sci  32: 100-104, 1996.
  5. G. Zandman-Goddard, J. George, Y. Levy, M. Blank, S. Slavin, Y. Shoenfeld. Modulation of experimental systemic lupus erythematosus with linomide. Lupus. 5; 328-333, 1996.
  6. G. Zandman-Goddard, J. George, V. Barak, M. Blank, Y. Levy, Y. Shoenfeld.  The effects of early and late administration of M20 IL-1 inhibitor on the manifestations of experimental systemic lupus erythematosus. Immunology Letters. 53; 77-82, 1996.
  7. M. Damianovich, B. Gilburd, J. George, N. Del Papa, A. Afek, I. Goldberg, Y. Kopolovic, D. Roth, G. Barkai, PL Meroni, Y. Shoenfeld. Pathogenic role of antiendothelial cell antibodies (AECA) in vasculitis: an idiotypic experimental model. The Journal of Immunology. 156; 4946-4951, 1996.
  8. Y. Levy Y, L. Ziporen, B. Gilburd, J. George, S. Polac-Charcon, H. Amital, J. Cledes, P. Youinou, Y. Shoenfeld.Membraneous nephropathy in primary antiphospholipid syndrome; description of a case and induction of renal injury in SCID mice.Human Antibodies Hybridomas. 7 91-96, 1996.
  9. A. Livneh, JPH. Drenth, IS. Klasen, P. Langevitz, J. George, D. Shelton, DL. Gumucio, E. Pras, DL. Kastner, M. Pras, JWM. van-der Meer. Familial mediterranean fever and hyperglobulinemia D syndrome: Two diseases with distinct clinical, serological and genetic features. Journal of Rheumatology. 24; 1558-1563, 1997.
  10. J. George, M. Blank, M. Hojnic, E. Bar-Meir, T. Koike, E. Matsuura, M. Lorber, M. Aviram, Y. Shoenfeld. Oxidized low density lipoprotein (oxLDL) but not LDL aggravates the manifestations of antiphospholipid syndrome (APS). Clinical and  Experimental Immunology. 108; 227-233, 1997.
  11. J. George, M. Blank, B. Gilburd, M. Hojnik, B. Shenkman, I. Tamarin, D. Varon, E. Matsuura, T. Koike, Y. Shoenfeld. Immunologic characterization and functional properties of murine antibodies raised against deleted mutants of human beta 2 glycoprotein I.International Immunology. 9; 913-921, 1997.
  12. J. George, B. Gilburd, Y. Levy, A. Afek, M. Damianovich, A. Doria, S Todesco, Y. Shoenfeld. “Autoantibody dominance” pattern following idiotypic manipulation of naive mice with different anti-U1RNP antibodies. Pathobiology. 65; 204-209, 1997.
  13. Y. Levy Y, J. George, L. Ziporen, J. Cledes, H. Amital, Y. Bar-dayan, A. Afek, P. Youinou, Y. Shoenfeld.
  14. Massive proteinuria as a main manifestation of primary antiphsopholipid syndrome. Pathobiology. 66: 49-52, 1998.
  15. J. George, A. Afek, B. Gilburd, Y. Levy, M. Blank, J. Kopolovic, D. Harats, Y. Shoenfeld.Atherosclerosis is accelerated in low-density receptor knockout mice by immunization with anticardiolipin antibodies Lupus. 6: 723-729, 1997.
  16. J. George, M. Blank, Y. Levy, PL. Meroni, M. Damianovitch, A. Tincani, Y. Shoenfeld. Differential effects of anti-b2 glycoprotein I antibodies on endothelial cells and on the manifestations of experimental antiphospholipid syndrome. Circulation. 97: 900-906, 1998.
  17. M. Blank, J. George, P. Fishman, Y Levy, V Toder, S Savion, Y, Shoenfeld. Ciprofloxacin immunomodulation of experimental antiphospholipid syndrome associated with elevation of IL-3 and GM-CSF expression. Arthritis and Rheumatism  41: 224-232, 1998.
  18. Y Levy, B Gilburd, J George, M Damianovich, M Blank, N Del-Papa, PL Meroni, P Youinou, Y Shoenfeld. Monoclonal murine antiendothelial cell antibodies (AECA)-characteristics and binding properties.International Immunology. 10: 861-868, 1998.
  19. M Galleazzi, F Bellisai, GD Sebastiani, G Morozzi, R Marcolongo, F Houssiau, R Cervera, Y Levy, J. George, Y Sherer, Y Shoenfeld. Association of 16/6 and SA1 anti-DNA idiotypes with anticardiolipin antibodies and clinical manifestations in a large cohort of SLE patients. European Concerted Action on the Immunogenetics of SLE. Clin Exp Rheumatology. 16: 717-720, 1998.
  20. J. George, A. Afek, B. Gilburd, Y. Levy, H. Levkovitz, A Shaish, I. Goldberg, J. Kopolovic, G. Wick, Y. Shoenfeld, D. Harats. Hyperimmunization of ApoE deficient mice with homologous malondialdehyde low-density lipoprotein suppresses early atherogenesis. Atherosclerosis. 138: 147-152, 1998.
  21. M. Blank, J. George, V. Barak, A. Tincani, T. Koike, Y. Shoenfeld. Oral tolerance to low dose b2GPI: immunomodulation experimental antiphospholipid syndrome. The Journal of Immunology. 161: 5303-5312, 1998.
  22. J. George, A. Afek, B. Gilburd, Y. Levy, A. Aron-Maor, A. Shaish, H. Levkovitz, M. Blank, D. Harats, Y. Shoenfeld. Induction of early atherosclerosis in LDL receptor deficient mice by immunization with beta 2 glycoprotein I. Circulation. 98: 1108-1115, 1998.
  23. J. George, M. Pantaik, E. Bakshi, Y. Levy. A. Ben David, A. Ahmed, JB Peter, Y. Shoenfeld.
  24. Seropositivity for Hantavirus in Isreali patients with end stage renal failure. Viral Immunology. 11: 103-108, 1998.
  25. J. George, B. Gilburd, M. Hojnik, Y. Levy, P. Langevitz, E. Matsuura, T. Koike, Y. Shoenfeld. Target recognition of b2-glycoprotein I (b2GPI)-dependent anticardiolipin antibodies: Evidence for involvement of the IV domain of b2GPI in antibody binding. The Journal of Immunology  32: 116-125, 1998.
  26. J. George, B. Gilburd, P Langevitz, Y. Levy, D. Harats, Y. Shoenfeld. b2-glycoprotein I containing immune complexes: association with thrombocytopenia and lipoprotein (a) levels.Lupus. 8: 116-120, 1999.
  27. J. George, Y. Shoenfeld, A. Afek, B. Gilburd, P. Keren, A. Shaish, Y. Kopolovic, D. Harats. Enhanced fatty streak formation C57BL/6J mice by immunization with heat shock protein 65. Arterioscler Thromb Vasc Biol. 19: 505-510, 1999.
  28. A. Afek, J. George, Y. Shoenfeld, B. Gilburd, Y. Levy, P. Keren, A. Shaish, D. Harats. Enhanced Atherosclerosis in ApoE deficient mice by immunization with b2-glycoprotein I Pathobiology. 67: 19-25, 1999.
  29. J. George, D. Harats, B. Gilburd, Y. Levy, P. Langevitz, Y. Shoenfeld. Atherosclerosis related markers in systemic lupus erythematosus patients: the role of humoral immunity in enhanced atherogenesis. Lupus. 8: 220-226, 1999.
  30. J. George, D. Harats, B. Gilburd, A. Afek, Y. Levy, J. Schneiderman, I. Barshack, J. Kopolovic, Y. Shoenfeld. Immunolocalization of b2-glycoprotein I to human atherosclerotic plaques: potential implications for lesion formation. Circulation. 99; 2227-2230, 1999.
  31. A Shaish, J. George, B Gilburd, P Keren, H Levkovitz, D Harats. Dietary b-carotene and a-tocopherol combination does not inhibit atherogenesis in an apoE deficient mouse model. Arterioscler Thromb Vasc Biol. 19:1470-1475, 1999.
  32. N. Zurgil, Y. Levy, K. Deutch, B. Gilburd, J. George, D. Harats, Y. Shoenfeld. Reactivity of peripheral blood lymphocytes (PBL) to oxidized LDL: a novel system to estimate atherosclerosis employing the cell scan.Clinical Cardiology. 22; 55-62, 1999.
  33. Y. Levy, Y. Sherer, J. George, P. Langevitz, A. Ahmed, Y. Bar-dayan, F. Fabrizzi, J. Terryberry, JB Peter, Y. Shoenfeld. Serologic and clinical response to treatment of systemic vasculitis associated autoimmune disease with intravenous immunoglobulin. Int Arch Allergy Immunol, 119; 231-238, 1999.
  34. J. George, A. Aron, Y. Levy, A. Ben-David, M. Hojnik, Y. Renaudineau, A. Zonana-Nachach, P. Youinou, D. Harats, Y. Shoenfeld. Anti-cardiolipin, anti-endothelial-cell and anti-malondialdehyde-LDL antibodies in uremic patients undergoing hemodialysis: relationship with vascular access thrombosis and thromboembolic events Human Antibodies. 9; 125-131, 1999.
  35. J. George, D. Harats, E. Bakshi, Y. Levy, Y. Adler, B. Gilburd, Y. Shoenfeld. Anti-oxidized-low density lipoprotein antibody determination as a predictor of restenosis following percutaneous transluminal coronary angioplasty. Immunology letters. 68; 263-266, 1999.
  36. J. George, Y. Shoenfeld, D. Harats. The involvement of b2-glycoprotein I in human and murine atherosclerosis. The Journal of Autoimmunity. 13; 57-60, 1999.
  37. Y. Levy, J. George, BA Sela, P Langevitz, D Hatats, Y Shoenfeld. Elevated homocysteine levels in patients with primary Raynaud’s syndrome. J.  Rheumatology. 26; 2383-2385. 1999.
  38. A Afek, R Manor, I Goldberg, L Ziporen, J. George, Polak-Charcon, MC Amigo, Garcia-Torres, R Segal, Y Shoenfeld, J Kopolovic. Increased endothelial cell expression of a3b1integrin in Libman-Sacks endocarditis in the antiphospholipid syndrome. Lupus. 8; 502-509, 1999.
  39. Y. Levy, Y. Sherer, A. Ahmed, P Langevitz, J. George, F. Fabrizzi, J. Terryberry, M. Lorber, JB. Peter, Shoenfeld Y. A study of 20 SLE patients with intravenous immunoglobulin-clinical and serologic response.Lupus  8; 705-712, 1999.
  40. A. Afek, J. George, B. Gilburd..D. Harats, Y. Shoenfeld.Immunization with heat shock protein 65 enhances early atherosclerosis in low-density lipoprotein receptor deficient mice. J. Autoimmunity. 14; 115-121, 2000.
  41. Levy Y. Y. Sherer, .J. George, J. Rovensky, J. Lukac, L. Rauova, P Porprac, P. Langevitz, F. Fabbrizzi, Y. Shoenfeld Intravenous gammaglobulin treatment of patients with lupus nephritis Semin. Arthritis Rheum. 29: 321-327, 2000.
  42. P. Keren, J. George, A. Shaish, H. Levkovitz, Z. Janakovic, A. Afek, I. Goldberg, J. Kopolovic, G. Keren, D. Harats. The effect of combined hyperglycemia and hyperlipidemia on atherosclerosis in LDL-receptor deficient mice: establishment of a combined model and association with heat shock protein 65 immunity. Diabetes. 49; 1064-1069. 2000.