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Biography

Dr. Xavier Palomer

Biomedical Research Center Network in Diabetes and Metabolic Diseases (CIBERDEM)

University of Barcelona, Spain


Email: xpalomer@ub.edu


Qualifications


2002     PhD at the Plant Molecular Biology Department (IBMB-CSIC)

1995     Bachelor degree in Biology at the University of Barcelona (UB)


Publications (Selected)

  1. Álvarez-Guardia D., Palomer X., Coll T., Davidson M.M., Chan T.O., Feldman A.M., Laguna J.C. and Vazquez-Carrera M. (2010). The p65 subunit of NF-kappaB binds to PGC-1alpha, linking inflammation and metabolic disturbances in cardiac cells. Cardiovasc Res 87, 449-458.
  2. Coll T., Barroso E., Álvarez-Guardia D., Serrano L., Salvadó L., Merlos M., Palomer X. and Vázquez-Carrera M. (2010). The Role of Peroxisome Proliferator-Activated Receptor b/d on the Inflammatory Basis of Metabolic Disease. PPAR Res 2010, 368467.
  3. Coll T., Álvarez-Guardia D., Barroso E., Gomez-Foix A.M., Palomer X., Laguna J.C. and Vazquez-Carrera M. (2010). Activation of Peroxisome Proliferator-Activated Receptor-{delta} by GW501516 Prevents Fatty Acid-Induced Nuclear Factor-{kappa}B Activation and Insulin Resistance in Skeletal Muscle Cells. Endocrinology 151, 1560-1569.
  4. Coll T., Palomer X., Blanco-Vaca F., Escola-Gil J.C., Sanchez R.M., Laguna J.C. and Vazquez-Carrera M. (2010). Cyclooxygenase 2 Inhibition Exacerbates Palmitate-Induced Inflammation and Insulin Resistance in Skeletal Muscle Cells. Endocrinology 151, 537-548.
  5. Álvarez-Guardia D., Palomer X., Coll T., Serrano L., Rodriguez-Calvo R., Davidson M.M., Merlos M., El Kochairi I., Michalik L., Wahli W. et al. (2011). PPARbeta/delta activation blocks lipid-induced inflammatory pathways in mouse heart and human cardiac cells. Biochim Biophys Acta 1811, 59-67.
  6. Barroso E., Rodriguez-Calvo R., Serrano-Marco L., Astudillo A.M., Balsinde J., Palomer X. and Vazquez-Carrera M. (2011). The PPAR{beta}/{delta} Activator GW501516 Prevents the Down-Regulation of AMPK Caused by a High-Fat Diet in Liver and Amplifies the PGC-1{alpha}-Lipin 1-PPAR{alpha} Pathway Leading to Increased Fatty Acid Oxidation. Endocrinology 152, 1848-1859.
  7. Barroso E., Eyre E., Palomer X. and Vazquez-Carrera M. (2011). The peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) agonist GW501516 prevents TNF-alpha-induced NF-kappaB activation in human HaCaT cells by reducing p65 acetylation through AMPK and SIRT1. Biochem Pharmacol 81, 534-543.
  8. Palomer X., Álvarez-Guardia D., Davidson M.M., Chan T.O., Feldman A.M. and Vazquez-Carrera M. (2011). The Interplay between NF-kappaB and E2F1 Coordinately Regulates Inflammation and Metabolism in Human Cardiac Cells. PLoS One 6, e19724.
  9. Serrano-Marco L., Rodriguez-Calvo R., El K., I, Palomer X., Michalik L., Wahli W. and Vazquez-Carrera M. (2011). Activation of Peroxisome Proliferator-Activated Receptor-{beta}/-{delta} (PPAR-{beta}/-{delta}) Ameliorates Insulin Signaling and Reduces SOCS3 Levels by Inhibiting STAT3 in Interleukin-6-Stimulated Adipocytes. Diabetes 60, 1990-1999.
  10. Mormeneo E., Jimenez-Mallebrera C., Palomer X., De N., V, Vazquez-Carrera M., Orozco A., Nascimento A., Colomer J., Lerin C. and Gomez-Foix A.M. (2012). PGC-1alpha Induces Mitochondrial and Myokine Transcriptional Programs and Lipid Droplet and Glycogen Accumulation in Cultured Human Skeletal Muscle Cells. PLoS One 7, e29985.
  11. Salvadó L., Serrano-Marco L., Barroso E., Palomer X. and Vázquez-Carrera M. (2012). Targeting PPARb/d for the treatment of type 2 diabetes mellitus. Expert Opin Ther Targets 16, 209-223.
  12. Serrano-Marco L., Barroso E., El K., I, Palomer X., Michalik L., Wahli W. and Vazquez-Carrera M. (2012). The peroxisome proliferator-activated receptor (PPAR) beta/delta agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells. Diabetologia 55, 743-751.
  13. Serrano-Marco L., Chacon M.R., Maymo-Masip E., Barroso E., Salvado L., Wabistch M., Garrido-Sanchez L., Tinahones F.J., Palomer X., Vendrell J. et al. (2012). TNF-alpha inhibits PPARbeta/delta activity and SIRT1 expression through NF-kappaB in human adipocytes. Biochim Biophys Acta 1821, 1177-1185.
  14. Barroso E., Valle J.D., Porquet D., Santos A.M., Salvado L., Rodriguez-Rodriguez R., Gutierrez P., nglada-Huguet M., Alberch J., Camins A. et al. (2013). Tau hyperphosphorylation and increased bace1 and rage levels in the cortex of PPARbeta/delta-null mice. Biochim Biophys Acta 1832, 1241-1248.
  15. Palomer X., Capdevila-Busquets E., Álvarez-Guardia D., Barroso E., Pallas M., Camins A., Davidson M.M., Planavila A., Villarroya F. and Vazquez-Carrera M. (2013). Resveratrol induces nuclear factor-kappaB activity in human cardiac cells. Int J Cardiol 167, 2507-2516.
  16. Palomer X., Salvado L., Barroso E. and Vazquez-Carrera M. (2013). An overview of the crosstalk between inflammatory processes and metabolic dysregulation during diabetic cardiomyopathy. Int J Cardiol 168, 3160-3172.
  17. Salvadó L., Coll T., Gomez-Foix A.M., Salmeron E., Barroso E., Palomer X. and Vazquez-Carrera M. (2013). Oleate prevents saturated-fatty-acid-induced ER stress, inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. Diabetologia 56, 1372-1382.
  18. Palomer X., Capdevila-Busquets E., Garreta G., Davidson M.M. and Vazquez-Carrera M. (2014). [PPARalpha attenuates palmitate-induced endoplasmic reticulum stress in human cardiac cells by enhancing AMPK activity.]. Clin Investig Arterioscler 26, 255-267.
  19. Palomer X., Capdevila-Busquets E., Botteri G., Salvado L., Barroso E., Davidson M.M., Michalik L., Wahli W. and Vazquez-Carrera M. (2014). PPARbeta/delta attenuates palmitate-induced endoplasmic reticulum stress and induces autophagic markers in human cardiac cells. Int J Cardiol 174, 110-118.
  20. Salvado L., Barroso E., Gomez-Foix A.M., Palomer X., Michalik L., Wahli W. and Vazquez-Carrera M. (2014). PPARbeta/delta prevents endoplasmic reticulum stress-associated inflammation and insulin resistance in skeletal muscle cells through an AMPK-dependent mechanism. Diabetologia 57, 2126-2135.
  21. Torres M., Palomer X., Montserrat J.M., Vazquez-Carrera M. and Farre R. (2014). Effect of ovariectomy on inflammation induced by intermittent hypoxia in a mouse model of sleep apnea. Respir Physiol Neurobiol 202, 71-74.
  22. Barroso E., Rodriguez-Rodriguez R., Chacon M.R., Maymo-Masip E., Ferrer L., Salvado L., Salmeron E., Wabistch M., Palomer X., Vendrell J. et al. (2015). PPARbeta/delta ameliorates fructose-induced insulin resistance in adipocytes by preventing Nrf2 activation. Biochim Biophys Acta 1852, 1049-1058.
  23. Chehaibi K., Cedo L., Metso J., Palomer X., Santos D., Quesada H., Naceur S.M., Wahli W., Julve J., Vazquez-Carrera M. et al. (2015). PPAR-beta/delta Activation Promotes Phospholipid Transfer Protein Expression. Biochem Pharmacol 94, 101-108.
  24. Massana L., Cabre A., Heras M., Amigó N., Correig X., Martínez-Hervás S., Real J.T., Ascaso J.F., Quesada H., Julve J. et al. (2015). Remarkable quantitative and qualitative differences in HDL after niacin or fenofibrate therapy in type 2 diabetic patients. Atherosclerosis 238, 213-219.
  25. Garcia-Ramirez M., Hernandez C., Palomer X., Vazquez-Carrera M. and Simo R. (2015). Fenofibrate prevents the disruption of the outer blood retinal barrier through downregulation of NF-kappaB activity. Acta Diabetol. In press.
  26. Salvadó L., Palomer X., Barroso E. and Vazquez-Carrera M. (2015). Targeting endoplasmic reticulum stress in insulin resistance. Trends Endocrinol Metab. In press.