Dr. Vladimir A. Kuznetsov

Senior Principal Investigator, Head of Division, Deputy Director Graduate Affairs

Genome and Gene expression Data Analysis

Bioinformatics Institute, Singapore

Email: vladimirk@bii.a-star.edu.sg

Qualifications

1992 Sci. D., Science-Technical Union of USSR Academy of Sciences, St.-Petersburg, Russia

1984  Ph.D., Moscow State University, Russia

Publications (Selected)

1. Wongsurawat T. Jenjaroenpun P, Kwoh CK, Vladimir Kuznetsov VA. Quantitative Model of R-loop Forming Structures Reveals a Novel Level of RNA-DNA Interactome Complexity. Nucleic Acids Research, 2011, 25 November, pp.1-15. Doi:10.1093/nar/gkr1075.
2. Migliori V, Muller J, Phalke S, Low D, Bezzi M, Mok WC, SahuSK,Gunaratne J, Capasso P, Bassi C, Cecatiello V, De Marco A, Blackstock V, Kuznetsov VA, Amati B, Mapelli M, and Guccione E. Symmetric Dimethylation of H3 Arginine 2 is a Novel Histone Mark that Supports Euchromatin Maintenance. Nature Structural Biol. 2012.
3. Kuznetsov VA. Relative avidity, specificity, and sensitivity of transcription factor-DNA binding in genome-scale experiments. Methods Mol Biol. 2009, 563:15-50.
4. Grinchuk OV, Jenjaroenpun P, Orlov YL, Zhou Jiangtao and Kuznetsov VA, Integrative analysis of the human cis-antisense gene pairs, miRNAs and their transcription regulation patterns, 2010, Nucleic Acids Research38(2): 534–547.
5. Ivshina AV, George J, Senko OV, Mow B, Putti TC, Smeds J, Nordgren H, Bergh J, Liu E T-B, Kuznetsov VA, Miller LD (2006) Genetic reclassification of histologic grade delineates new clinical subtypes of breast cancer. Cancer Res. 66, 10292-10301.
6. Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao XD, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. (2006). The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006 38(4):431-440. Epub 2006 Mar 5.
7. Liu ET., Kuznetsov VA. Miller LD. In the pursuit of complexity: Systems medicine in cancer biology. Cancer Cell 2006, 9, 245-247
8. Wei CL., Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao XD, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y (2006) A global map of p53 transcription-factor binding sites in the human genome. Cell 124(1):207-219.
9. Zucchi, I., Mento, E., Kuznestov, VA., Scotti, M., Valsecchi, V. Simionati, B., Valle, G., Pilotti, S., Vicinanza, E., Reinbold, R., Vezzoni, P, Albertini, A. and Dulbecco, R. (2004) Gene expression profiles of  epithelial microscopically  isolated from breast-invasive ductal carcinoma and nodal metastasis. PNAS USA, 101, 18147-18152.
10. Kuznetsov VA,Knott GD, Bonner RF (2002) General statistics of stochastic process in Eukaryotic cells. Genetics 161(3), 1321-1332.

Profile Details

http://www.bii.a-star.edu.sg/research/gagd/gagd.php