Dr. Elisabetta Renzoni

Royal Brompton Hospital, UK

Email: e.renzoni@imperial.ac.uk

Qualifications

2008 Ph.D., Imperial College, London, UK

1988 B.Sc., Medical Degree, University of Siena, Italy

Publications (selected)

1. Visca D, Montgomery A, de Lauretis A, Sestini P, Soteriou H, Maher TM, Athol Wells AU, Renzoni EA. Ambulatory oxygen in interstitial lung diseases. Eur Respir J, in press (Oct 2011).
2.  Corte TJ, Copley SJ, Desai SR, Zappala CJ, Hansell DM, Nicholson AG, Colby TV, Renzoni E, Maher TM, Wells AU. Significance of Connective Tissue Disease features in Idiopathic Interstitial Pneumonia. Eur Respir J. 2011 Sep 20. [Epub ahead of print]
3. de Lauretis A, Veeraraghavan S, Renzoni E. Review series: Aspects of Interstitial lung disease: connective tissue disease-associated interstitial lung disease: how does it differ from IPF? How should the clinical approach differ? Chron Respir Dis. 2011;8:53-82.
4. Verma H, Nicholson AG, Kerr KM, Dempsey OJ, Gibbs AR, Campbell I, Black F,Rassl D, Rice AJ, Renzoni EA, Wells AU, Hansell DM. ALVEOLAR PROTEINOSIS WITH HYPERSENSITIVITY PNEUMONITIS - A NEW CLINICAL PHENOTYPE. Respirology. 2010 Aug 25. [Epub ahead of print] PubMed PMID:20920129.
5. Corte TJ, Ellis R, Renzoni EA, Hansell DM, Nicholson AG, du Bois RM, Wells AU. Use of intravenous cyclophosphamide in known or suspected, advanced non-specific interstitial pneumonia. Sarcoidosis Vasc Diffuse Lung Dis. 2009 Jul;26(2):132-8. PubMed PMID: 20560293.
6. Fonseca C, Abraham D, Renzoni EA. Endothelin in Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2010 May 6. [Epub ahead of print] PubMed PMID: 20448055.
7. Asher MI, Stewart AW, Mallol J, Montefort S, Lai CK, Aït-Khaled N, Odhiambo J; ISAAC Phase One Study Group. Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One. Respir Res. 2010 Jan 21;11:8. Review. PubMed PMID:20092649; PubMed Central MCID: PMC2831000.
8. Rossi A, Sozio F, Sestini P, Renzoni EA, Khan K, Denton CP, Abraham DJ, Weber E. Lymphatic and blood vessels in scleroderma skin, a morphometric analysis. Hum Pathol. 2010 Mar;41(3):366-74. Epub 2009 Dec 11. PubMed PMID: 20004944; PubMed Central PMCID: PMC2829123.
9. Zappala CJ, Latsi PI, Nicholson AG, Colby TV, Cramer D, Renzoni EA, Hansell DM, du Bois RM, Wells AU. Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis. Eur Respir J. 2010 Apr;35(4):830-6. Epub 2009 Oct 19. PubMed PMID: 19840957.
10. Renzoni EA. Interstitial lung disease in systemic sclerosis. Monaldi Arch Chest Dis. 2007;67:217-28. Review.
11. Shi-wen X, Kennedy L, Renzoni EA, Bou-Gharios G, du Bois RM, Black CM, Denton CP, Abraham DJ, Leask A. Endothelin is a downstream mediator of profibrotic responses to transforming growth factor beta in human lung fibroblasts. Arthritis Rheum. 2007;56:4189-94.
12. Fonseca C, Lindahl GE, Ponticos M, Sestini P, Renzoni EA, Spagnolo P, Pantelidis P, Leoni P, Holmes AM, McHugh N, Stock CJ, Shi-Wen X, Denton CP, Black CM, Welsh KI, du Bois RM, Abraham DJ. A Functional Polymorphism in the CTGF Promoter is Associated with Risk of Systemic Sclerosis” New Engl Journal Medicine 2007 (in press)
13. Abdallah AM, Renzoni EA, Anevlavis S, Lagan AL, Munkonge FM, Fonseca C, Black CM, Briggs D, Wells AU, Marshall SE, McHugh N, du Bois RM, Welsh KI. A polymorphism in the promioter region of the CD86 (B7.2) gene is associated with systemic sclerosis. Int J Immunogenet 2006 Jun;33:155-61.
14. Fonseca C, Renzoni E, Sestini P, Pantelidis P, Lagan A, Reilly JJ, Bunn C, McHugh N, Welsh KI, du Bois RM, Denton CP, Black C, Abraham D. Endothelin axis polymorphisms in scleroderma patients. Arthritis & Rheum 2006; 54:3034-42.
15. Menon RP, Menon MR, Shi-Wen X, Renzoni E, Bou-Gharios G, Black CM, Abraham DJ. Hammerhead ribozyme-mediated silencing of the mutant fibrillin-1 of tight skin mouse: Insight into the functional role of mutant fibrillin-1. Exp Cell Res 2006 Feb 17; Epub ahead of print.
16. Shi-Wen X, Stanton L, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA,Carter DE, Bou-Gharios G, Stratton R, Pearson JD, Beier F, Lyons KM, Black CM, Abraham DJ, Leask A. CCN2 is necessary for adhesive responses to TGFbeta 1 in embryonic fibroblasts. J Biol Chem 2006 Feb 16; Epub ahead of print.
17. Chen Y, Shi-Wen X, van Beek J, Kennedy L, McLeod M, Renzoni EA, Bou-Gharios, G, Wilcox-Adelman S, Goetinck PF, Eastwood M, Black CM, Abraham DJ, Leask A. Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.Am J Pathol 2005;167:1699-711.
18. Spagnolo P, Renzoni EA, Wells AU, Copley SJ, Desai SR, Sato H, Grutters JC, Abdallah A, Taegtmeyer A, du Bois RM, Welsh KI. C-C chemokine receptor 5 gene variants in relation to lung disease in sarcoidosis. Am J Respir Crit Care Med 2005 15;172:721-8.
19. Renzoni EA, Abraham DJ, Howat S, Shi-Wen X, Sestini P, Bou-Gharios G, Wells AU, Veeraraghavan S, Nicholson AG, Denton CP, Leask A, Pearson JD, Black CM, Welsh KI, du Bois RM. Gene expression profiling reveals novel TGFβ targets in adult lung fibroblasts. Respiratory Research 2004; 30;5:24.
20. Lagan AL, Pantelidis P, Renzoni EA, Fonseca C, Beirne P, Taegtmeyer AB, Denton CP, Black CM, Wells AU, du Bois RM, Welsh KI. Single-nucleotide polymorphisms in the SPARC gene are not associated with susceptibility to scleroderma. Rheumatology 2005;44:197-201.
21. Lawson WE, Grant SW, Ambrosini V, Womble KE, Dawson EP, Lane KB, Markin C, Renzoni E, Lympany P, Thomas AQ, Roldan J, Scott TA, Blackwell TS, Phillips III JA, Loyd JE, du Bois RM. Genetic Mutations in Surfactant Protein C Are a Rare Cause of Sporadic Cases of IPF. Thorax 2004;59:977-80.
22. Ujita M, Renzoni EA, Veeraraghavan S, Wells AU, Hansell DM. Organizing pneumonia: perilobular pattern at thin-section CT. Radiology 2004;232:757-61.
23. Renzoni EA. Neovascularization in idiopathic pulmonary fibrosis: too much or too little? Am J Respir Crit Care Med 2004;169:1179-80.
24. Shi-Wen X, Chen Y, Denton CP, Eastwood M, Renzoni EA, Bou-Gharios G, Pearson JD, Dashwood M, DuBois RM, Black CM, Leask A, Abraham DJ. Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/PI3 kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts. Mol Biol Cell 2004;15:2707-19.
25. Shi-Wen X, Howat SL, Renzoni EA, Holmes A, Pearson JD, Dashwood MR, Bou-Gharios G, Denton CP, DuBois RM, Black CM, Leask A, Abraham DJ. Endothelin-1 induces expression of matrix-associated genes in lung fibroblasts through MEK/ERK. J Biol Chem 2004 28;279:23098-103.

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