Dr. Raymond Chuen-Chung Chang
Department of Anatomy
The University of Hong Kong, China
Email: rccchang@hku.hk
Qualifications
1997 Ph.D., University of Munich
Publications (selected)
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Cheung YT, Zhang NQ, Hung CHL, Lai CSW, Yu MS, So KF and Chang RCC* (2011) Temporal Relationships of autophagy and neuronal apoptosis in low molecular weight β-amyloid peptide neurotoxicity. J. Cell. Mol. Med., 15, 244-257.
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Ho YS, Chiu K, Hung CHL, So KF and Chang RCC (2011) Holistic approach versus scientific evidence, what do we know about anti-aging herbal medicine in aging-associated neurodegenerative diseases? In: Akhlaq A. Farooqui Ed. Phytochemicals and Human Health: Pharmacological and Molecular Aspects. Nova Publisher (Book Chapter). In press.
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Ho YS, So KF and Chang RCC (2011) Drug discovery from Chinese Medicine against neurodegeneration in Alzheimer’s and vascular dementia. CHINESE MEDICINE, 6: 15.
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Ho YS, Hung CHL, Chang RCC (2011) Green tea and neurodegeneration in Alzheimer’s disease. In: Victor R. Preedy Ed. Tea in Health and Disease Prevention Elsevier Publisher (Book Chapter). In Press.
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Lau BW, Ren C, Yang J, L Yan SW, Chang RCC, Pu M, So KF (2011) Light deprivation induces depression-like behavior and suppresses neurogenesis in diurnal Mongolian gerbil (Meriones unguiculatus). Cell Transplant., In press.
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Li SY, Yang D, Yeung CM, Yu WY, Chang RCC, So KF, Wong D, Lo ACY (2011) Lycium barbarum polysaccharides reduce neuronaldamage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. Plos One, e16380.
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Chiu K, Liang YX, Chang RCC, So KF (2011) Lycium barbarum L.: a neuroprotective drug for glaucoma. Ophthalmol. CHN., 20, 21-27.
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Chiu K, Chan TF, Wu A, Leung IYP, So KF, Chang RCC (2011) Neurodegeneration in the retina of mouse models of Alzheimer’s disease: what can we learn from the retina? AGE, In Press.
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Chiu K, So KF, Chang RCC (2011) Immune modulation in glaucoma - can manipulation on microglia activation help? In: Tomaš Kubena Ed. Glaucoma, Book 2; InTech Open Access Publisher (Book Chapter). In press.
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Ho YS, Yu MS, Yang X, So KF, Yuen WH and Chang RCC (2010) Neuroprotective effects of polysaccharides from Wolfberry antagonize homocysteine-induced toxicity in rat cortical neurons. J. Alzheimer Dis., 19, 813-827.
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Ho YS, So KF and Chang RCC (2010) Anti-aging herbal medicine – how and why can they be used in aging-associated neurodegenerative diseases? Ageing Res. Rev., 9, 354-362.
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Wuwongse S, Chang RCC and Law ACK (2010) The putative neurodegenerative links between depression and Alzheimer’s disease. Prog. Neurobiol., 91, 362-375.
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Chao J, Li H, Cheng KW, Yu MS, Chang RCC and Wang M (2010) Protective effects of pinostilbene, a resveratrol methylated derivative, against 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. J. Nutr. Biochem., 21, 482-489.
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Chiu K, Yeung SC, So KF and Chang RCC (2010) Modulation of morphological changes of microglia and neuroprotection by monocyte chemoattractant protein-1 in experimental glaucoma. Cell. Mol. Immunol., 7, 61-68.
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Yu HT, Chan WWL, Chai KH, Lee CWC, Chang RCC, Yu MS, McLoughlin DM, Miller CCJ and Lau KF (2010) Transcriptional regulation of human FE65, a ligand of Alzheimer’s disease amyloid precursor protein, by Sp1. J. Cell. Biochem., 109, 782-783.
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Cheung YT, Lau WKW and Chang RCC (2010) What do we need to concern in using cell line for neurotoxicology research, differentiation or disturbance of intracellular signaling? NeuroToxicology, 31, 164-166.
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Chao J, Lau KW, Huie MJ, Ho YS, Yu MS, Lai CSW, Wang M, Yuen WH, Lam WH, Chan TH and Chang RCC (2010) A pro-drug of the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) prevents differentiated SH-SY5Y cells from toxicity induced by 6-hydroxydopamine. Neurosci. Letters, 469, 360-364.
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Chiu K, Zhou Y, Yeung SC, Lok CKM, Chan OOC, Chang RCC, So KF and Chiu JF (2010) Up-regulation of crystallins is involved in neuroprotective effects of Wolfberry on survival of retinal ganglion cells in rat ocular hypertension model. J. Cell. Biochem., 110, 311-320.
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Hung CHL, Ho YS and Chang RCC (2010) Modulations of mitochondrial calcium as a pharmacological target for Alzheimer’s disease. Ageing Res. Rev., 9, 447-456.
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Peng X, Ma J, Chao J, Sun Z, Chang RCC, Tse I, Li ETS, Chen F and Wang M (2010) Beneficial effects of cinnamon proanthocyanidins on the formation of specific glycation endproducts and methylglyoxal-induced impairment on glucose consumption. J. Arg. Food Chem., 58, 6692-6696.
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Zheng ZP, Ma J, Cheng KW, Chao J, Zhu Q, Chang RCC, Zhao M, Lin ZX, Wang M. (2010) Sulfur-containing constituents and one 1H-pyrrole-2-carboxylic acid derivative from pineapple [Ananas comosus (L.) Merr.] fruit. Phytochemistry, 71, 2046-2051.
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Chang RCC, Ho YS, Yu MS and So KF (2010) Medicinal and nutraceutical uses of wolfberry in preventing neurodegeneration in Alzheimer’s disease. In: Charles Ramassamy and Stéphane Bastianetto Eds. Recent Advances on Nutrition and Alzheimer’s disease. (Book Chapter). pp. 169-185.
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Chang RCC, Chao J, Yu MS and Wang M (2010) Neuroprotective effects of oxyresveratrol from fruit against neurodegeneration in Alzheimer’s disease. In: Charles Ramassamy and Stéphane Bastianetto Eds. Recent Advances on Nutrition and Alzheimer’s disease. (Book Chapter). pp. 155-168.
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So KF and Chang RCC (2010) Ginseng, Wolfberry, Bilberry in “Section 8: Non-pharmaceutical Medications and Approaches”. In: R.N. Weinreb & J. Liebmann Ed. Medical Treatment of Glaucoma: World Glaucoma Association Consensus Series 7. Kugler Publication (Book Chapter). pp. 237-242.