Biography

Prof. Hironobu Ihn

Kumamoto University, Japan

 

Email: ihn-der@kumamoto-u.ac.jp

 

Qualifications

 

1998 Ph.D., University of Tokyo, Japan

1990 M.D., University of Tokyo, Japan

 

Publications (Selected)

  1. Makino T, Johno T, Fukushima S, Wakasugi S, Inoue Y, Ihn H.  Decreased serum IL-7 levels in patients with systemic sclerosis. Clin Exp Rheumatol 54s: 68-69, 2009.
  2. Miyashita A, Jono T, Makino T, Yoshino Y, Ihn H.  Lupus erythematosus profundus: clinical and pathological features of 12 cases. Arch Dermatol Res 301: 51, 2009 (abstract).
  3. Ohshima Y, Yajima I, Yanagishita T, Kumasaka MY, Yanagishita T, Watanabe D, Takahashi M, Inoue Y, Ihn H, Matsumoto Y, Kato M.  CD109 expression levels in human malignant melanoma. J Dermatol Sci, 57: 132-146, 2010.
  4. Matsuda M, Hoshino T, Yamashita Y, Tanaka KI, Maji D, Sato K, Adachi H, Sobue G, Ihn H, Funasaka Y, Mizushima T.  Prevention of ultraviolet B radiation-induced epidermal damage by expression of heat shock protein 70. J Biol Chem, 285: 5848-5858, 2010.
  5. Nishi H, Inoue Y, Kageshita T, Takata M, Ihn H.  The expression of human high molecular weight melanoma-associated antigen in acral lentiginous melanoma. Bioscience Trends, 4: 86-89. 2010.
  6. Akiyama M, Sakai K, Yanagi T, Fukushima S, Ihn H, Hitomi K, Shimizu H.  Transglutaminase 1 preferred substrate prptide K5 is an efficient tool in diagnosis of lamellar ichthyosis. Am J Pathol, 176: 1592-1599, 2010. 
  7. Igata T, Jinnin M, Makino T, Moriya C, Muchemwa F, Ishihara T, Ihn H.  Up-regulated type I collagen expression by the inhibition of Rac1 signaling pathway in human dermal fibroblasts. Biochem Biophys Res Commun, 393: 101-105, 2010.
  8. Hoshino T, Matsuda M, Yamashita Y, Takehara M, Fukuya M, Mineda K, Maji D, Ihn H, Adachi H, Sobue G, Funasaka Y, Mizushima T.  Supression of melanin production by expression of HSP70. J Biol Chem, 285: 13254-13263, 2010.
  9. Makino T, Jinnin M, Muchemwa F, Fukushima S, Ihn H.  Basic fibroblast growth factor stimulates the proliferation of human dermal fibroblasts via the ERK1/2 and JNK pathways. Br J Dermatol, 162: 717-723, 2010.
  10. Jinnin M, Makino T, Kajihara I, Honda N, Makino K, Ogata A, Ihn H.  Serum levels of soluble vascular endothelial growth factor receptor-2 in patients with systemic sclerosis. Br J Dermatol, 162: 751-758, 2010.
  11. Muchemwa FC, Jinnin M, Wakasugi S, Sakamoto M, Inoue Y, Ishihara T, Ihn H.  A novel COL1A1 exon 14/PDGFB fusion gene in dermatofibrosarcoma protuberans, Eur J Dermatol, 20: 390-391, 2010.
  12. Muchemwa FC, Wakasugi S, Honda Y, Ihn H.  PDGFB quantification is a useful tool in the diagnosis of dermatofibrosarcoma protuberans: a study of 10 cases. Clin Exp Dermatol, 35: 295-299, 2010.
  13. Torii H, Nakagawa H, Iizuka H, Aoyagi S, Okuyama R, Ohtsuki M, Abe M, Takamori K, Matsuba S, Terui T, Igarashi A, Kawashima M, Amagai M, Takae Y, Eto H, Ikeda S, Komine M, Saeki H, Hayakawa K, Kitami A, Watanabe H, Takehara K, Shimada S, Kitajima Y, Takigawa M, Morita A, Yamanaka K, Takahashi K, Tarutani M, Tani M, Kubota Y, Nakayama J, Ihn H.  Inflixmab monotherapy in Japanese patients with moderate-to-severe plaque psoriasis and psoriatic arthritis. A randomized, double-blind, placebo-controlled multicenter trial. J Dermatol Sci, 59: 40-49, 2010.
  14. Kato T, Inoue Y, Ishihara T, Kageshita T, Ihn H.  Amelanotic malignant melanoma where primary lesion was discovered 5 years after metastasis in the lymph node. J Dermatol, 37: 730-734, 2010.
  15. Higashi-Kuwata N, Jinnin M, Makino T, Fukushima S, Inoue Y, Muchemwa FC, Yonemura Y, Komohara Y, Takeya M, Mitsuya H, Ihn H.  Characterization of monocyte/macrophage subsets in the skin and peripheral blood derived from patients with systemic sclerosis. Arhritis Res Ther, 12: R128 (1-10), 2010.
  16. Kawashima T, Tada Y, Asano Y, Yazawa N, Tomita M, Tamaki Z, Kubo M, Ihn H, Sugaya M, Kadono T, Tamaki K, Sato S.  Serum TARC/CCL17 levels are increased in dermatomyositis associated with interstitial lung disease. J Dermatol Sci, 60: 52-54, 2010.
  17. Honda N, Jinnin M, Kajihara I, Makino T, Fukushima T, Ihn H.  Impaired lymphangiogenesis due to excess VEGF-D/Flt-4 signaling in the skin of patients with systemic sclerosis. Br J Dermatol, 163: 776-780, 2010.
  18. Nakashima T, Jinnin M, Etoh T, Fukushima S, Masuguchi S, Maruo K, Inoue Y, Ishihara T, Ihn H.  Down-regulation of mir-424 contributes to the abnormal angiogenesis via MEK1 and cyclin E1 in senile hemangioma: its implications to therapy. PloS One, 5: e14334, 2010.
  19. Kawashita Y, Jinnin M, Makino T, Kajihara I, Makino K, Honda N, Masuguchi S, Fukushima S, Inoue Y, Ihn H.  Circulating miR-29a levels in patients with scleroderma spectrum disorder. J Dermatol Sci, 61: 67-69, 2011.
  20. Asano Y, Ihn H, Jinnin M, Tamaki K.  Altered dynamics of TGF-b receptors in scleroderma fibroblasts. Ann Rheum Dis, 70: 384-387, 2011.
  21. Moriya C, Jinnin M, Yamane K, Maruo K, Muchemwa FC, Igata T, Makino T, Fukushima S, Ihn H.  Expression of matrix metalloproteinase-13 is controlled by IL-13 via PI3K/Akt3 and PKC-d in normal dermal fibroblasts. J Invest Dermatol, 131:  655-661, 2011.
  22. Kanemura H, Fukushima S, Yamashita J, Honda N, Oyama R, Kakimoto A, Masuguchi S, Ishihara T, Inoue Y, Jinnin M, Ihn H.  Circulating microRNA-221 level in patients with malignant melanoma as a new tumor marker. J Dermatol Sci, 61: 187-193, 2011.
  23. Oyama R, Jinnin M, Kakimoto A, Kanemura H, Ichihara A, Fujisawa A, Honda N, Masuguchi S, Fukushima S, Maruo K, Ihn H.  Circulating microRNA associated with TNF signaling pathway in patients with plaque psoriasis. J Dermatol Sci, 61: 209-211, 2011.
  24. Makino K, Fukushima S, Maruo K, Egawa K, Nishimoto K, Ihn H.  Cutaneous hyalohyphomycosis by Scedosporium apiospermum in an immunocompromised patient. Mycoses, 54: 259-261, 2011.
  25. Xie Y, Jinnin M, Zhang X, Wakasugi S, Makino T, Inoue Y, Masuguchi S, Sakai K, Jinnin M, Ihn H.  Immunohistochemical characterization of the cellular infiltrate in discoid lupus erythematosus. BioScience Trends, 5: 83-88, 2011.
  26. Arakawa H, Jinnin M, Muchemwa FC, Makino T, Kajihara I, Makino K, Honda N, Sakai K, Fukushima S, Ihn H.  Adiponectin expression is decreased ininvolved skin and sera of diffuse cutaneous scleroderma patients. Exp Dermatol, 20: 764-766, 2011.
  27. Masuguchi S, Jinnin M, Fukushima S, Makino T, Sakai K, Inoue Y, Igata T, Ihn H.  The expression of HER-2 in extramammary Paget’s disease. BioScience Trends, 5: 151-155, 2011.
  28. Kuwata N, Makino T, Inoue Y, Ihn H.  Expression pattern of VEGF-1, -2, -3, and D2-40 protein in the skin of patients with systemic sclerosis. Eur J Dermatol, 21: 490-494, 2011.
  29. Maekawa T, Jinnin M, Ihn H.  The expression levels of thrombospondin-1 in dermatofibroma and dermatofibrosarcoma protuberans. Eur J Dermatol, 21: 534-538, 2011.
  30. Ichihara A, Jinnin M, Yamane K, Fujisawa A, Sakai K, Masuguchi S, Fukushima S, Maruo K, Ihn H.  micro-RNA mediated keratinocyte hyperproliferation in psoriasis. Br J Dermatol, 165: 1003-1010, 2011.
  31. Yamada M, Sakai K, Hayashi M, Hozumi Y, Abe Y, Kawaguchi M, Ihn H, Suzuki T. Oculocutaneous Albinism Type 3: A Japanese girl with novel mutations in TYRP1 gene. J Dermatol Sci, 64: 217-222, 2011.
  32. Jinnin M, Fukushima S, Masuguchi S, Tanaka H, Kawashita Y, Ishihara T, Ihn H.  Evaluation of usefulness of 3D views for clinical photography. BioScience Trends, 5: 211-216, 2011.
  33. Aoi J, Endo M, Kadomatsu T, Miyata K, Nakano M, Horiguchi H, Ogata A, Odagiri H, Yano M, Araki K, Jinnin M, Ito T, Hirakawa S, Ihn H, Oike Y.  The chronic inflammatory mediator angiopoietin-like protein 2 contributes to carcinogenesis and cancer cell metastasis. Cancer Res, 71：7502-7512, 2011.

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