Dr. Xianxin
Hua
University of
Pennsylvania, USA
Email:
huax@mail.med.upenn.edu
Qualifications
1995 Ph.D.,
University of Texas Southwestern Medical Center, USA
1986 M.S.,
Hubei Medical College, China
1983 M.D.,
Hubei Medical College, China
Publications
(Selected)
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Wu, T., Zhang,
X., Huang, X., Yang, Y. and Hua, X. Regulation of cyclin B2 expression and G2/M
transition by menin. Journal of Biological Chemistry. Jun 1,; 85(24):18291-300.
2010.
-
Zi-Jie Feng,
Shu-Bin Gao, Yuan Wu, Xiang-Fan Xu, Xianxin Hua, Guang-Hui Jin. Lung cancer
cell migration is regulated via repressing growth factor PTN/ RPTP β/ζ
signaling by menin. Oncogene. 2010, 9;28(46):4095-104.
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Aggarwal P,
Pontano Vaites L, Kim JK, Mellert H, Gurang B, Hua X, Nakagawa H, Herlyn M,
Rustgi AK, McMahon SB and Diehl JA. Nuclear Cyclin D1/CDK4 Kinase Regulates
Cul4 Expression and Tumorigenesis via Activation of the PRMT5
Methyltransferase. Cancer Cell. 2010. Cancer Cell. Oct 19; 18(4):329-40. 2010.
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Yang, Y.,
Gurung, B., Wu, T., Wang, H., Stoffers, D. A. and Hua, X. Reversal of
pre-existing hyperglycemia in diabetic mice by acute deletion of Men1. Proc
Natl Acad Sci U S A. Nov 23; 107(47):20358-63. 2010.
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Maillard I,
Chen YX, Friedman A, Yang Y, Tubbs AT, Shestova O, Pear WS, Hua, X. Menin
regulates the function of hematopoietic stem cells and lymphoid progenitors.
Blood. Feb 19;113(8):1661-9. 2009.
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J Yan, Y Yang,
H Zhang, C King, HM Kan, Y Cai, CX Yuan, GS Bloom, and X Hua. Menin Interacts
with IQGAP1 to Enhance Intercellular Adhesion of beta Cells. Oncogene.Feb
19;28(7):973-82. 2009.
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Gao, SB.,
Feng, ZJ., Xu, B., Wu, Y., Yin, P., Yang, Y., Hua, X., Jin, GH.
Suppression of lung adenocarcinoma through menin and polycomb gene-mediated
repression of growth factor pleiotrophin. Oncogene. 19;28(46):4095-104.2009.
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Manabu
Hashimoto, Satoru Kyo, Xianxin Hua, Hidetoshi Tahara, Miki Nakajima, Masahiro
Takakura, Junko Sakaguchi, Yoshiko Maida, Mitsuhiro Nakamura, Tomomi Ikoma,
Yasunari Mizumoto and Masako Inoue. Role of menin in the regulation of
telomerase activity in normal and cancer cells. Int J Oncol. 33(2):333-40.
2008.
-
Gao, S, Hua, X
and Jin G. Menin Regulates Endocrine Diseases by Controlling Histone
Modification and Gene Transcription. Ann of Endocrinology (France).
Nov;69(5):426-32. Epub 2008 Aug 26. Review. 2008.
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Wu, X. and
Hua, X. Menin, Histone H3 Methyltransferases, and Regulation of Cell
Proliferation: Current Knowledge and Perspective. Current Molecular Medicine.
Dec; 8(8):805-15. Review. 2008.
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Yang, Y. and
Hua, X. In search of the function of tumor suppressor menin.
Molecular and Cellular Endocrinology. Feb;265-266:34-41. Epub 2007
Jan 11. 2007.
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Wu XJ and Hua
X. Targeting ROS: Selective Killing of Cancer Cells by a Cruciferous Vegetable
Derived Pro-Oxidant Compound. Cancer Biol Ther. May; 6(5):646-7. Epub 2007 Mar
1. 2007.
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Ping La,
Yuqing Yang, Satyajit K. Karnik, Albert C. Silva, Robert W. Schnepp, Seung K.
Kim and Hua X.. Menin-mediated caspase 8 expression in suppressing multiple
endocrine neoplasia type 1. J Biol Chem. Oct 26; 282(43):31332-40. 2007.
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Claudia D.
Andl, Brenton B. Fargnoli, Takaomi Okawa , Mark Bowser, Munenori Takaoka,
Hiroshi Nakagawa, Andres Klein-Szanto, Xianxin Hua, Meenhard Herlyn and Anil K.
Rustgi. Coordinated functions of E-cadherin and TGF receptor II in
vitro and in vivo. Cancer Research. Oct 15; 66(20):9897-85. 2006.
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Jizhou Yan,
Angela Desmond, Albert Silva, Ya-Xiong Chen, Yuqing Yang, Haoren Wang, and Hua,
X. Cdx4 and menin co-regulate Hoxa9 expression in hematopoietic cells. PLoS
ONE. Dec 20;1:e47. 2006.