Prof. Zhizhou Zhang

Harbin Institute of Technology, China

Professor

Email: zhangzzbiox@gmail.com

Qualifications

2000 Ph.D., Medical College of Ohio (at Toledo), Biochemistry and Mol. Biology, Functional dissection of the global transcriptional repressor Tup1 in Saccharomyces cerevisiae

1990 B.S., University of Science and Technology of China, Hefei, Anhui, China, Molecular Biology. Expression, purification and characterization of recombinant SubtilisinE derivatives in Bacillus subtilis

Publications (Selected)

1. Local gene network pattern (LGNP) approach to tackle mechanisms of complicated phenotypes: local network structure of hypertension related genes. Zhizhou Zhang*, Yun Wang, Xiujin Wang, Xiao Han, and Changjin Liu. iCBBE2008, IEEE, Shanghai,2008.
2. Zhizhou Zhang*, Lijun Chang, Xiujin Wang,Yun Wang and Cheng Zhang. APCH2007, 2007, Beijing.
3. Convergence Analysis of Genetic Regulatory Networks based on Nonlinear Measures. Hongtao Lu, Zhizhou Zhang and Lin He. The International Symposium on Neural Networks (ISNN2005). Springer Lecture Notes in Computer Science 3496: 247-252, 2005.
4. Engineered internal noise stochastic resonator in gene network: A model study. Zhiwei Wang, Zhonghuai Hou, Houwen Xin, Zhizhou Zhang*. Biophysical Chemistry 125 (2007) 281–285.
5. Nanoparticle PCR: Nanogold-assisted PCR with enhanced specificity. Haikuo Li, Jiehuan Huang, Xiaodong Zhang, Zhizhou Zhang*, Chunhai Fan* and Jun Hu*. Angew. Chem. Int. Ed. 2005, 44(32):5100-3.
6. Aqueous suspension of carbon nanopowder enhances the efficiency of polymerase chain reaction. Zhizhou Zhang*, Mingchun Wang and Hongjie An. Nanotechnology, 18 (2007) 355706.
7. Aqueous suspension of carbon nanotubes enhances the efficiency of long PCR. Zhizhou Zhang*, Cencao Shen, Mingchun Wang and Xiaohong Cao. 2008, Biotechniques, 44(4):537-545. About the authors: Teda Bio-X Center for Systems Biotechnology. Biotechniques, 2008, 44(4):463.
8. GSAC 2005, Genomes, Medicine and the Environment. The Venter Institute.October 17–19,2005,USA. Nano-particles are reshaping recombinant DNA technologies. Zhizhou Zhang.
9. Construction of Molecular Logic Gates with a DNA-Cleaving Deoxyribozyme. Xi Chen, Yifei Wang, Zhizhou Zhang*, Chunhai, Fan* and Lin He*. 2006。Angew. Chem. Int. Ed.. Vol.118( 11 ): 1791 – 1794.
10. Differential dependence on DNA ligase of type II restriction enzymes: A practical way toward ligase-free DNA automaton. Peng Chen , Jing Li , Jian Zhao , Lin He , Zhizhou Zhang*. Biochem. Biophys. Res. Commun. 353(3), 16 February 2007, 733-737.
11. Development of nano-scale DNA computing devices. Zhizhou Zhang* et al. Current Nanoscience, 2005， Vol. 1, No. 1, pp 91 – 95.
12. Linearly programmed DNA-based molecular computer operated on magnetic particle surface in test-tube. Jian Zhao#, Zhizhou Zhang#*, Yongyong Shi, Jixia Liu and Lin He*. 2004. Chinese Science Bulletin, Vol 49, No.1, 17-22.
13. 13.A Double-SVM Classification System for Single and Multiple-Subcellular Localizations of Yeast Proteins using Sequence Motifs. Su Zhang, Wei Yang, Ning Wu, Yazhu Chen, Hongtao Lu, Zhizhou Zhang. IEEE ICIA-2007,July 9-11, Jeju City, Korea. P173-176.
14. Functional dissection of the global repressor Tup1 in yeast: dominant role of the C-terminal repression domain overlapping the first WD repeat. 2002. Zhizhou Zhang, Usha Varanasi, and Robert Trumbly. Genetics 161:957-969. 2002.
15. Structural and functional study of the WD repeats in Tup1: folding properties of the trypsin-resistant core WD2-6. Zhizhou Zhang, Usha Varanasi, Pauline Carrico, and Robert J. Trumbly. Archives of Biochemistry and Biophysics 406:47-54,2002.
16. Application of Pseudo Amino Acid Composition for Predicting Protein Subcellular Location: Yu-Xi Pan, Zhi-Zhou Zhang, Zong-Ming Guo, Guo-Yin Feng, Zhen-De Huang,and Lin He. Journal of Protein Chemistry, 22（4）, 395-402. 2003.
17. DNA Computing and Genomics. Zhizhou Zhang*, Lin He. Invited. High Capacity Computing，2005，Vol.3,p13-17。(in Chinese)
18. DNA Add Using Linear Self-Assembly. Lulu Qian, Jian Zhao, Qiang Liu*, Zhizhou Zhang* and Lin He*. Chinese Science Bulletin, 52(11),1462—1467, 2007.
19. Mechanism of improved inclusion body dissolvement under alkaline conditions. Zhizhou Zhang, Yuying Zhang, Kaiyu Yang. Science of China(C),1997,27(2):103-108.
20. Purification and characterization of alkaline protease SubtilisinE from Bacillus subtilis. Xianshun Wang, Yang Lu, Zhizhou Zhang,etc. Progress in Biochemistry and Biophysics,1992,19(5):398-400.