Dr. Kejie Yin

Department of Neurology

University of Pittsburgh School of Medicine, USA

Email: yink2@upmc.edu

Qualifications

1998  Ph.D., Shanghai Medical University, Shanghai, China

1990  M.S., Nanjing Medical University, Nanjing, China

1983  M.D., Yangzhou University Medical College, Yangzhou, China

Publications (Selected)

1. Yin KJ, Dai XZ Distribution of somatostatin mRNA in rat area postrema revealed by in situ hybridization histochemistry. Chinese Science Bulletin 1994; 39(22): 2091-2094.

2. Yin KJ Distribution of somatostatin mRNA containing neurons in the primary pain relaying nuclei of the rat.  The Anatomical Record 1995; 241(4): 579-584.

3. Yin KJ, Sun FY Altered expression of glutamate transporter GLASTmRNA in rat brain after photochemically-induced focal ischemia. The Anatomical Record   1998; 251: 9-14.

4. Yin KJ, Sun, FY Theneuroprotective action of dextromethophan in the rat photochemically-induced focal ischemia. ActaPharmacologicaSinica 1998; 19(3): 223-226.

5. Yin KJ, Sun FY Effect of dextromethorphan, a NMDA antagonist, on DNA repair in rat photochemical thrombotic cerebral ischemia. Brain Research 1999; 815:29-35.

6. Yin KJ, JuurlinkBHJ Regulation of expression of nuclear factor kappa B RelA in oligodendrocytes: effect of hypoxia. NeuroReport 2000; 11(9): 1877-1881.

7. Yin KJ, Chen SD, Lee JM, Xu J and Hsu CY   ATM gene regulates OGD-induced NF-kB DNA–binding activity and downstream apoptotic cascade in mouse cerebral vascular endothelial cells. Stroke 2002; 33:2471-2477.

8. Yin KJ, Lee JM, Chen SD, Xu J and Hsu CY  Amyloid beta Induces smac release via AP-1/Bim activation in cerebral endothelial cells.  Journal of Neuroscience 2002; 22(22): 9764–9770.

9. Lee JM, Yin KJ, Hsin I, Chen SW, Fryer J, Hsu CY, Holtzman D, Xu J Matrix metallopreteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy. Annals of Neurology 2003;54:379-382.

10. Lee JM, Yin KJ, Hsin I, Chen S, Fryer JD, Holtzman DM, Hsu CY, Xu J. Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage. Journal of the Neurological Sciences 2005; 229-230: 249-254.

11. Yin KJ, Lee JM, Xu J, Hsu CY.  Abeta (25-35) alters Akt activity, resulting in Bad translocation and mitochondrial dysfunction in cerebrovascular endothelial cells. Journal of Cerebral Blood Flow and Metabolism 2005;25:1445-1455.

12. Yin KJ, Lee JM, Kim GM, Xu J, Hsu CY. JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury. Neurobiology of Disease  2005; 20:881-889.

13. Yin KJ, Hsu CY, Hu XY, Chen H, Chen SW, Xu J, Lee JM. PP2A regulates Bim expression via inactivation of Akt/FKHRL1 signaling pathway in Aβ-induced cerebrovascular endothelial cell death. Journal of Neuroscience 2006; 26(8):2290-2299.

14. Yin KJ, Cirrito JR, Yan P, Hu XY, Xiao QL, Pan XO, Bateman R, Song HW, Hsu FF, Turk J, Xu J, Hsu CY, Mills JC, Holtzman DM, Lee JM. Matrix metalloproteinases expressed by astrocytes mediate extracellular Aβ catabolism. Journal of Neuroscience 2006; 26(43):10939-10948.

15. He X, Mo X, Gu H, Chen F, Gu Q, Peng W, Qi J, Shen L, Sun J, Zhang R, Yin KJ. Neuroprotective effect of diazoxide on brain injury induced by cerebral ischemia/reperfusion during deep hypothermia. Journal of the Neurological Sciences 2008; 268:18-27.

16. Yin KJ, Deng Z, Huang HR, Hamblin M, Xie CQ, Zhang JF, Chen YE. miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia.  Neurobiology of Disease 2010; 38:17-26.

17. Yin KJ, Deng Z, Hamblin M, Huang HR, Xiang Y, Zhang JF, Wang YZ, Chen YE. PPARδ regulation of miR-15a in ischemia-induced vascular endothelial injury.  Journal of Neuroscience 2010; 30(18):6398-6408.

18. Yin KJ, Deng Z, Hamblin M, Zhang JF, Chen YE. Vascular PPARδ protects against stroke-induced brain injury.  Arteriosclerosis, Thrombosis, and Vascular Biology 2011; 31(3):574-81.

19. Yin KJ, Olson K, Hamblin M, Zhang JF, Schwendeman SP, Chen YE. Vascular endothelial cell-specific microRNA-15a inhibits angiogenesis in hindlimb ischemia. Journal of Biological Chemistry 2012; 287(32): 27055-27064.

20. Yin KJ, Fan YB, Hamblin M, Zhang JF, Li S, Hawse JR, Subramaniam M, Song CZ, Urrutia R, Lin JD,  Chen YE.  KLF11 mediates PPARg cerebrovascular protection in ischemic stroke.  Brain 2013; 136:1274-1287.

21. Yin KJ, Hamblin M, Chen YE. Angiogenesis-regulating microRNAs and ischemic stroke.  Current Vascular Pharmacology 2013 May; [Epub ahead of print].

22. Yin KJ, Hamblin M, Zhang J, Chen YE. Non-coding RNAs and cerebrovascular endothelial pathophysiology in stroke. Neurochemistry International 2014;77:9-16.

23. Yin KJ, Hamblin M, Fan Y, Zhang J, Chen YE. Krüppel-like factors in the central nervous system: novel mediators in Stroke. Metabolic Brain Disease 2015; 30 (2): 401-410.