Advances in Eicosanoid

Eicosanoids are signaling molecules made by the enzymatic or non-enzymatic oxidation of arachidonic acid or other polyunsaturated fatty acids (PUFAs) that are, similar to arachidonic acid, around 20 carbon units in length. Eicosanoids are a sub-category of oxylipins, i.e. oxidized fatty acids of diverse carbon units in length, and are distinguished from other oxylipins by their overwhelming importance as cell signaling molecules. 

In the present book, ten typical literatures about eicosanoid published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on eicosanoid. We hope this book can demonstrate advances in eicosanoid as well as give references to the researchers, students and other related people.

Sample Chapter(s)
preface (96 KB)
Components of the Book:
  • Chapter 1
    Eicosanoid and eicosanoid-related inflammatory mediators and exercise intolerance in heart failure with preserved ejection fraction
  • Chapter 2
    The FADS1 genotypes modify the effect of linoleic acid‑enriched diet on adipose tissue inflammation via pro‑inflammatory eicosanoid metabolism
  • Chapter 3
    A genome-wide association study identifies 41 loci associated with eicosanoid levels
  • Chapter 4
    Tissue pretreatment for LC–MS/MS analysis of PUFA and eicosanoid distribution in mouse brain and liver
  • Chapter 5
    Eicosanoid lipidome activation in post‑mortem brain tissues of individuals with APOE4 and Alzheimer’s dementia
  • Chapter 6
    SILAC‑based quantitative proteomics to investigate the eicosanoid associated inflammatory response in activated macrophages
  • Chapter 7
    Nanomolar EP4 receptor potency and expression of eicosanoid‑related enzymes in normal appearing colonic mucosa from patients with colorectal neoplasia
  • Chapter 8
    A single extraction 96-well method for LC-MS/MS quantification of urinary eicosanoids, steroids and drugs
  • Chapter 9
    Eicosanoids in the Pancreatic Tumor Microenvironment—A Multicellular, Multifaceted Progression
  • Chapter 10
    Mild COVID-19 imprints a long-term inflammatory eicosanoidand chemokine memory in monocyte-derived macrophages
Readership: Students, academics, teachers and other people attending or interested in Eicosanoid.
Emily S. Lau
Division of Cardiology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA

Maija Vaittinen
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, 70210 Kuopio, Finland

Eugene P. Rhee
Nephrology Division and Endocrine Unit, Massachusetts General Hospital, Boston, MA, USA

Madlen Reinicke
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Leipzig University, Liebigstr. 27,04103 Leipzig, Germany

Brandon Ebright
School of Pharmacy, University of Southern California, Los Angeles, USA

Ulrike Ries Feddersen
Digestive Disease Center, Bispebjerg Hospital, 2400 Copenhagen NV,Denmark

and more...
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