Glial Cells in Health and Disease

Neuroglia, also called glial cells or simply glia, are non-neuronal cells in the central nervous system (brain and spinal cord) and the peripheral nervous system. They maintain homeostasis, form myelin, and provide support and protection for neurons. In the central nervous system, glial cells include oligodendrocytes, astrocytes, ependymal cells, and microglia, and in the peripheral nervous system glial cells include Schwann cells and satellite cells. They have four main functions: (1) To surround neurons and hold them in place (2) To supply nutrients and oxygen to neurons (3) To insulate one neuron from another (4) To destroy pathogens and remove dead neurons. They also play a role in neurotransmission and synaptic connections, and in physiological processes like breathing.


In the present book, twelve typical literatures about glial cells published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on Neural Precursor Cells, Brain Tumors, Psychopathology and Brain Philosophy, Neurotransmission and Central nervous system, etc. We hope this book can demonstrate advances in glial cells as well as give references to the researchers, students and other related people.


Components of the Book:
  • Chapter 1
    Glial cells are functionally impaired in juvenile neuronal ceroid lipofuscinosis and detrimental to neurons
  • Chapter 2
    Activation of PKC triggers rescue of NPC1 patient specific iPSC derived glial cells from gliosis
  • Chapter 3
    Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells
  • Chapter 4
    Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated gliosis
  • Chapter 5
    Neural stem/progenitor cells react to non-glial cns neoplasms
  • Chapter 6
    Glial contributions to neurodegeneration in tauopathies
  • Chapter 7
    Effects of dexamethasone and meloxicam on Borrelia burgdorferi-induced inflammation in glial and neuronal cells of the central nervous system
  • Chapter 8
    Crosstalk between glial and glioblastoma cells triggers the “go-or-grow” phenotype of tumor cells
  • Chapter 9
    Vascular, glial, and lymphatic immune gateways of the central nervous system
  • Chapter 10
    Tumour-associated glial host cells display a stem-like phenotype with a distinct gene expression profile and promote growth of GBM xenografts
  • Chapter 11
    Impact of Elastin-Derived Peptide VGVAPG on Matrix Metalloprotease-2 and -9 and the Tissue Inhibitor of Metalloproteinase-1, -2, -3 and -4 mRNA Expression in Mouse Cortical Glial Cells In Vitro
  • Chapter 12
    Effects of environmental enrichment on white matter glial responses in a mouse model of chronic cerebral hypoperfusion
Readership: Students, academics, teachers and other people attending or interested in glial cells study.
Rosella Abeti, Department of Molecular Neuroscience, Institute of Neurology, University College London, London, UK

Payam Rezaie, Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes, UK

Simon Pope, Genetics and Genomic Medicine UCL Great Ormond Street Institute of Child Health, University College London, London, UK

Jonathan D. Cooper, Department of Pediatrics, Harbor-UCLA Medical Center, Los Angeles Biomedical Research Institute and David Geffen School of Medicine UCLA, Torrance, USA

Franziska Peter, Albrecht-Kossel-Institute for Neuroregeneration (AKos), University Medicine Rostock, Rostock, Germany

Tatiana Barichello, Center for Translational Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas at Houston, Houston, USA

and more...
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