Mind in Aging

Herein, we present a monograph entitled “Mind in Aging” for young scientists who wish to study traditional Japanese Kampo medicine. This monograph describes more than two decades of our research and represents the work of many young scientists who dedicated their time to accomplish this program. We are sincerely grateful to these participants, and the names of each are listed in the chapter acknowledgments.


Life-threatening diseases, such as cancer, heart disease, autoimmune disease, and obesity will hopefully be eliminated sometime in the relatively near future. However, mysteries and diseases of the mind will likely remain unsolved for a longer time. Daily activities of learning and memory retrieval, thinking and thought, and perception all stimulate a feeling of mind. Without learning and memory, thinking and thought, as well as perception, are not enough to recognize self-existence and will not stimulate a feeling of mind. For the past several decades, we have studied learning and memory, thinking and thought, and the sensibility of perception in experimental animals in order to unlock the mysteries of the mind, particularly with regard to aging.

Components of the Book:
  • FRONT MATTER
  • Chapter A: Introduction
  • Chapter B: Age‐Related Brain Changes
    • 1. Development of Advanced Glycation end Products (AGE) in Relation to Neuronal Cell Death in the Hippocampus and Entorhinal Cortex in Aging, and the Therapeutic Efficacy of Toki-Shakuyaku-San (TSS)
    • 2. TSS Reverses Age-Related Declines in Memory
  • Chapter C: Retrieval of Memory in Transgenic Mutant Mice Lacking Pituitary Adenylate Cyclase Activating Polypeptide Type 1 Receptor (PAC1‐R)
    • 1. Consolidation of Learning into Long-Term Memory
  • Chapter D: Thinking and Thought Disorders in Transgenic Mutant Mice Lacking PAC1‐R
    • 1. The Application of the Paradigm Task A→Task B→Task A for Investigation of Thinking and Thought Disorders
  • Chapter E: Perception in Transgenic Mutant Mice Lacking PAC1‐R Performing on Memory Task
    • 1. Exploratory-Related Behavior in New Environment
    • 2. Visual Orientation and Retrieval of Memory
    • 3. Geomagnetic Orientation and Retrieval of Memory
    • 4. Fear Conditions and Memory Retrieval
  • Chapter F: Mind in Aging and Performance of Memory Tasks
    • 1. Age-Related Changes of Anxiety Perceptions and Memory Retrieval
    • 2. Deficits of Cholinergic Afferents in the Hippocampus and Perception of Anxiety and Memory Retrieval
  • Chapter G: Conclusion
  • Chapter H: Glossaries
Readership: Scientists, Scientific enthusiasts who are interested in Aging issue.
1
FRONT MATTER
PDF (8803 KB)
9
Chapter A: Introduction
PDF (134 KB)
14
Chapter B: Age‐Related Brain Changes
PDF (11588 KB)
45
Chapter C: Retrieval of Memory in Transgenic Mutant Mice Lacking Pituitary Adenylate Cyclase Activating Polypeptide Type 1 Receptor (PAC1‐R)
PDF (6355 KB)
54
Chapter D: Thinking and Thought Disorders in Transgenic Mutant Mice Lacking PAC1‐R
PDF (5323 KB)
64
Chapter E: Perception in Transgenic Mutant Mice Lacking PAC1‐R Performing on Memory Task
PDF (21396 KB)
110
Chapter F: Mind in Aging and Performance of Memory Tasks
PDF (2990 KB)
127
Chapter G: Conclusion
PDF (100 KB)
128
Chapter H: Glossaries
PDF (132 KB)
Dr. Nobuyoshi Hagino (Biography), Laboratory of Integrative Medicine, US-Japan Cooperative Biomedical Research Laboratories, Tulane University Hebert Research Center, and Department of Medicine, Tulane University School of Medicine, Belle Chasse, Louisiana, U.S.A.

Dr. Shinjiro Kobayashi (Biography), Department of Clinical Pharmacy, Hokuriku University Faculty of Pharmaceutical Sciences, Kanagawa-machi, Kanazawa, Japan

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