In chemistry, a multi-component reaction (or MCR), sometimes referred to as a “Multi-component Assembly Process” (or MCAP), is a chemical reaction where three or more compounds react to form a single product. By definition, multicomponent reactions are those reactions whereby more than two reactants combine in a sequential manner to give highly selective products that retain majority of the atoms of the starting material. Multicomponent reactions have been known for over 150 years. Isocyanide based MCRs are most frequently exploited because the isocyanide is an extraordinary functional group. It is believed to exhibit resonance between its tetravalent and divalent carbon forms. This induces the isocyanide group to undergo both electrophilic and nucleophilic reactions at the CII atom, which then converts to the CIV form in an exothermic reaction. The occurrence of isocyanides in natural products has also made it a useful functional group.

In the present book, ten typical literatures about multi-component reaction published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on chemical kinetics, chemical synthesis, chemical engineering, ect. We hope this book can demonstrate advances in multi-component reaction as well as give references to the researchers, students and other related people.