Advances in Antivirals Drugs Strategies

Antiviral drugs are a class of medication used specifically for treating viral infections. Like antibiotics and broad-spectrum antibiotics for bacteria, most antivirals are used for specific viral infections, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do not destroy their target pathogen; instead they inhibit their development. The general idea behind modern antiviral drug design is to identify viral proteins, or parts of proteins, that can be disabled. Once targets are identified, candidate drugs can be selected, either from drugs already known to have appropriate effects, or by actually designing the candidate at the molecular level with a computer-aided design program. The target proteins can be manufactured in the lab for testing with candidate treatments by inserting the gene that synthesizes the target protein into bacteria or other kinds of cells. The cells are then cultured for mass production of the protein, which can then be exposed to various treatment candidates and evaluated with “rapid screening” technologies.

 

In the present book, fifteen typical literatures about antiviral drugs strategies published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on medical science, hemadenology, virology, epidemiology, ect. We hope this book can demonstrate advances in antiviral drugs strategies as well as give references to the researchers, students and other related people.

Components of the Book:
  • Chapter 1
    Strategies to Develop Antivirals against Enterovirus 71
  • Chapter 2
    Can Informal Social Distancing Interventions Minimize Demand for Antiviral Treatment during a Severe Pandemic?
  • Chapter 3
    Are There National Strategies, Plans and Guidelines for The Treatment of Hepatitis C in People Who Inject Drugs? A Survey of 33 European Countries
  • Chapter 4
    Managing HIV/Hepatitis C Co-Infection in the Era of Direct Acting Antivirals
  • Chapter 5
    A Model-Based Economic Analysis of Pre-Pandemic Influenza Vaccination Cost-Effectiveness
  • Chapter 6
    Chronic Viral Hepatitis: Policy, Regulation, and Strategies for Its Control and Elimination in Ethiopia
  • Chapter 7
    Hepatitis C in the Era of Direct-Acting Antivirals: Real-World Costs of Untreated Chronic Hepatitis C; A Cross-Sectional Study
  • Chapter 8
    A Human Renal Proximal Tubule Cell Line with Stable Organic Anion Transporter 1 and 3 Expression Predictive for Antiviral-Induced Toxicity
  • Chapter 9
    Facilitators of HCV Treatment Adherence among People Who Inject Drugs: A Systematic Qualitative Review and Implications for Scale Up of Direct Acting Antivirals
  • Chapter 10
    Present, Old and Future Strategies for Anti-HCV Treatment in Patients Infected by Genotype-1: Estimation of the Drug Costs in the Calabria Region in the Era of the Directly Acting Antivirals
  • Chapter 11
    Virus-Host Interactomics: New Insights and Opportunities for Antiviral Drug Discovery
  • Chapter 12
    Influenza Vaccines and Influenza Antiviral Drugs in Africa: Are They Available and Do Guidelines for Their Use Exist?
  • Chapter 13
    How to Approach and Treat Viral Infections in ICU Patients
  • Chapter 14
    Design of Non-Pharmaceutical Intervention Strategies for Pandemic Influenza Outbreaks
  • Chapter 15
    Ethics-Sensitivity of the Ghana National Integrated Strategic Response Plan for Pandemic Influenza
Readership: Students, academics, teachers and other people attending or interested in Antivirals Drugs Strategies
Shin-Ru Shih
Research Center for Emerging Viral Infections, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan

Amy L. Greer
Professional Guidelines and Public Health Practice Division, Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, ON, Canada

Jürgen K. Rockstroh
Department of Medicine I, University Hospital Bonn, Sigmund-Freud-Str. 25, Bonn, Germany

Joel K. Kelso
School of Computer Science and Software Engineering, The University of Western Australia, 35 Stirling Highway, Crawley, WA, Australia

Carlo Torti
Unit of Infectious Diseases, University “Magna Graecia”, Catanzaro, Italy

Jazmin Duque
International Epidemiology and Research Team, Epidemiology Branch, Influenza Division, U.S. Centers for Disease Control and Prevention, Atlanta, GA, USA

and more...
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