Advances in Targeted Cancer Therapy

Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules (“molecular targets”) that are involved in the growth, progression, and spread of cancer. Targeted cancer therapies are sometimes called “molecularly targeted drugs,” “molecularly targeted therapies,” “precision medicines,” or similar names. Targeted therapies are currently the focus of much anticancer drug development. They are a cornerstone of precision medicine, a form of medicine that uses information about a person’s genes and proteins to prevent, diagnose, and treat disease. Many targeted cancer therapies have been approved by the Food and Drug Administration (FDA) to treat specific types of cancer. Others are being studied in clinical trials (research studies with people), and many more are in preclinical testing (research studies with animals).

 

In the present book, fifteen typical literatures about targeted cancer therapies published on international authoritative journals were selected to introduce the worldwide newest progress, which contains reviews or original researches on medical science, bioinformatics, oncology, epidemiology, ect. We hope this book can demonstrate advances in targeted cancer therapies as well as give references to the researchers, students and other related people.

Components of the Book:
  • Chapter 1
    Molecular Targeted Therapy for the Treatment of Gastric Cancer
  • Chapter 2
    The Progress of Targeted Therapy in Advanced Gastric Cancer
  • Chapter 3
    HAI-178 Antibody-Conjugated Fluorescent Magnetic Nanoparticles for Targeted Imaging and Simultaneous Therapy of Gastric Cancer
  • Chapter 4
    Targeted Therapy for HER2 Positive Breast Cancer
  • Chapter 5
    Radium-223 Dichloride Bone-Targeted Alpha Particle Therapy for Hormone-Refractory Breast Cancer Metastatic to Bone
  • Chapter 6
    Down Regulation of SPAG9 Reduces Growth and Invasive Potential of Triple-Negative Breast Cancer Cells: Possible Implications in Targeted Therapy
  • Chapter 7
    The Research and Applications of Quantum Dots as Nano-Carriers for Targeted Drug Delivery and Cancer Therapy
  • Chapter 8
    Targeted Enzyme Prodrug Therapy for Metastatic Prostate Cancer – A Comparative Study of L-Methioninase, Purine Nucleoside Phosphorylase, and Cytosine Deaminase
  • Chapter 9
    Monitoring Metabolic Response Using FDG PET-CT during Targeted Therapy for Metastatic Colorectal Cancer
  • Chapter 10
    Novel Reversible Selective Inhibitor of CRM1 for Targeted Therapy in Ovarian Cancer
  • Chapter 11
    In Vitro Prediction of the Efficacy of Molecularly Targeted Cancer Therapy by Raman Spectral Imaging
  • Chapter 12
    Individualizing Kinase-Targeted Cancer Therapy: The Paradigm of Chronic Myeloid Leukemia
  • Chapter 13
    In-Silico Discovery of Cancer-Specific Peptide-HLA Complexes for Targeted Therapy
  • Chapter 14
    Survival, Healthcare Resource Use and Costs among Stage IV ER + Breast Cancer Patients Not Receiving HER2 Targeted Therapy: A Retrospective Analysis of Linked SEER-Medicare Data
  • Chapter 15
    Safe and Targeted Anticancer Therapy for Ovarian Cancer Using a Novel Class of Curcumin Analogs
Readership: Students, academics, teachers and other people attending or interested in Targeted Cancer Therapy
Rui-hua Xu
Department of Medical Oncology, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China

Janice Lu
Department of Medicine, State University of New York at Stony Brook Medical Center, Stony Brook, NY, USA

Vivek Subbiah
Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

Roger G. Harrison
Bioengineering Center and the School of Chemical, Biological and Materials Engineering, University of Oklahoma, Norman, OK, USA

Klaus Gerwert
Department of Biophysics, Ruhr University Bochum, Universit?tsstr. 150, Bochum, Germany

Michael W. Deininger
Huntsman Cancer Institute, The University of Utah, Circle of Hope, Salt Lake City, UT, USA

and more...
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